objective: silicon is an effective element in bone biomineralization; hence si-substituted hydroxyapatite can be a relevant bioceramic as bone materials substitution. materials and methods: stoichiometric hydroxyapatite (ha) and si-substituted hydroxyapatite (si-ha) with different contents of si substitution were synthesized successfully by a hydrothermal method using ca(no3)2, (nh4)3po4 or (n...

background and objectives: helicobacter pylori is the causative agent of peptic ulcer disease and a co-factor in development of gastric malignancies. lps are among toxic substances produced by h. pylori exhibiting low endotoxic activity compared to typical bacterial lps. the aim of this study was to investigate bioactivity of lps produced by different serotypes of helicobacter pylori compared t...

introduction: glass-ionomer cements (gics) are one of the most important dental restorative biomaterials. the aim of this study was to synthesize glass-ionomer‒silk fiber composite and evaluate the effect of adding natural degummed silk fiber on the bioactivity and the ability to release fluoride by glass-ionomer cement. materials and methods: in this study, commercial fuji ii glass-ionomer cem...

in this work, we report the effect of biopolymers (starch and gelatin) on in vitro biocompatibility property of nano hydroxyapatite (nhap) composites. cell culture and mtt assays were performed for in vitro biocompatibility. they show that nhap can affect the proliferation of cells and the nhap-starch and nhap-gelatin biocomposites have no negative effect on the cell morphology, viability and p...

background : immunogenicity of streptokinase (stk), as a thrombolytic drug, have limited its clinical use. elimination of the amino acid residues that are responsible for immunogenicity while don’t affect the bioactivity of stk is worthy. recently, we modified the stk through elimination of 42 amino acids from its’ c-terminal and assessed its bioactivity in vitro . objective : in this study, bi...

this work was to isolate and identify the bioactive secondary metabolite which was produced by myxobacterium stigmatella eracta wxnxj-b, and to evaluate its antitumor and apoptosis-inducing effects. the results showed that one novel compound (molecular formula c29h25no3) was isolated, purified by sephadex lh-20 column chromatography and preparative rp-hplc, and identified as 5-(6-benzyl-quinoli...

osseointegration has been the concern of implantology for many years. researchers have used various ceramic coatings for this purpose; however, piezoelectric ceramics (e.g., barium titanate [bto]) are a novel fi eld of interest. in this regard, bto (batio3 , bto) coating was fabricated by electrophoretic deposition on ti6al4v medical alloy, using sol-gel-synthesized nanometer bto powder. struct...

the aim of this work was to investigate the effect of silica coating on bioactivity and biodegradability of hydroxyapatite. in this purpose, we firstly attempted to synthesis hydroxyapatite (ha) nanoparticles and its silica coated (si-ha) sample in collagen matrix using calcium chloride, sodium phosphate and sodium silicate. characterization of the sample was carried out using fourier transform...

objective anti-rh d igg is used for the prevention of anti-d antibody production in rh- individuals who have been exposed to rh+ red blood cells. the stability of igg preparations as a solution is low, with a shelf life of a year or more. formulation of anti-rh d igg as a lyophilized preparation would decrease its degradation rate and increases its shelf life. the objective of this study was to...