bleomycin (blm)as an anti-cancer agent causes tissue toxicities through dna damaging and cell deaths. the aim of this study was to investigate the effects of thymol against genotoxicity and anti-proliferation induced by blm in normal human lymphocytes and ovarian cancer cells.peripheral blood samples were collected from human volunteers and were incubated with thymolat different concentrations ...

objective: cd44+/cd24-/low breast cancer cells have tumour-initiating properties with stem cell-like features. breast cancer gene 1 (brca1) is a tumour suppressor gene that plays a crucial role in dna repair and maintenance of chromosome stability. the clinicopathological features of breast cancer in brca1 mutation carriers suggest that brca1 may function as a stem-cell regulator. materials and...

objective: prostate cancer is the second most common cancer worldwide. chemotherapeutic agents have been shown to have adverse side-effects, and natural compounds have been recommended for cancer treatment, nowadays. crab shell has been shown to have cancer preventative and suppressive effects in vivo and in vitro. the aim of present study was to investigate the effect of crab shell extract on ...

parthenolide is major sesquiterpene lactones present in anthemis haussknechtii boiss. & reut. (feverfew). this compound has many effects on different disease such as migrain and cancer. parthenolide was reported from tanacetum parthenium (l.) sch.bip. but other plants of asteraceae family could contain parthenolide. in this study parthenolide was extracted and identified with two methods, fouri...

Objective(s): Breast cancer is a devastating disease related to women. The anticancer properties of 8-hydroxyquinoline (8HQ) and the increasing use of graphene oxide (GO), as a drug delivery system with anti-cancerous properties, led us to investigate the toxicity and apoptosis-induction capability of 8HQ-coated GO on breast cancer cells compared with normal breast cel...

malignant tumors of head and neck carcinomas are the sixth most common type of cancer. current systemic therapies for cancer show side effects in normal tissues and short-term efficacy due to drug resistance. consequently, there is much interest in identifying new drugs for cancer treatment. crocin (an active ingredient of saffron) has been shown to have cytotoxic effects on cancer cell lines. ...

Background: Breast cancer is the most common female malignancy and the leading cause of cancer mortality in women worldwide. The human epidermal growth factor receptor2 (HER2) is a transmembrane tyrosine kinase receptor that is usually overexpressed in human breast cancers. Stable cell lines heterogeneously overexpressing HER2 are highly required as in vitro models for breast cancer research. T...