how to cite this article: ashrafimr, azizi malamiri r, zamani gr, mohammadi m, hosseini f. sleep inducing for eeg recording in children: a comparison between oral midazolam and chloral hydrate. iran j child neurol. 2013 winter;7(1):15-19. objective electroencephalography (eeg) recording is a long duration procedure that needs patient’s cooperation for device setup and performing the procedure. ...

AIM We hypothesised that chloral hydrate is safe and effective for sedation during dental treatments for children with mild asthma. We evaluated the safety and efficacy of chloral hydrate by measuring changes in heart rate (HR), transcutaneous oxygen saturation, (SpO2), asthma score, behaviour, types and frequency of adverse reactions associated with chloral hydrate were assessed throughout tre...

OBJECTIVE Electroencephalography (EEG) recording is a long duration procedure that needs patient's cooperation for device setup and performing the procedure. Many children lose their cooperation during this procedure. Therefore, sedation and sleep are frequently induced using a few agents as pre procedure medication in children before EEG recording. We aimed to compare the sedative effects of o...

Four different methanotrophs expressing soluble methane monooxygenase produced 2,2,2-trichloroacetaldehyde, or chloral hydrate, a controlled substance, during the oxidation of trichloroethylene. Chloral hydrate concentrations decreased in these cultures between 1 h and 24 h of incubation. Chloral hydrate was shown to be biologically transformed to trichloroethanol and trichloroacetic acid by Me...

In examining how chloral hydrate affects mitosis, we found that extracellular application of 0.1% chloral hydrate produced an abrupt rise in cytosolic free Ca2+. Digitized fluorescence microscopy of Fura-2-loaded, mitotic and interphase PtK cells revealed that Ca2+ rose 15 s after chloral hydrate application, peaked within 1 min at a concentration two- to sevenfold above the basal level and the...

OBJECTIVE Sleep is a known activator of epileptiform discharges on electroencephalography. Chloral hydrate is used frequently for electroencephalography sedation. Our objectives were to study the value and limitations of chloral hydrate. METHODS One hundred and fifty nine consecutive pediatric electroencephalograms were included prospectively. One electroencephalography technologist collected...

Major uses Chloral hydrate (synthesized in 1832 and introduced into medicine 1869) is the oldest member of sedative-hypnotic drugs. To the same group belong paraldehyde, bromide, urethane, and sulfonal. Metabolite of chloral hydrate, trichloroethanol, is also an excellent hypnotic agent, but is not often used as such due to its physical and irritant properties. At present, chloral hydrate is la...

We conducted this single blind randomized clinical trial to compare the efficacy and safety of oral chloral hydrate and intranasal midazolam for induction of sedation for computerized tomography scan of brain in children. Participants aged 1-10 years (n=60) were randomized to receive 100 mg/kg chloral hydrate orally with intra nasal normal saline OR intranasal midazolam 0.2 mg/kg with oral norm...

BACKGROUND There are recent reports on several anesthetics that have anti-inflammatory and anti-infective effects apart from their uses for pain relief and muscle relaxation. Chloral hydrate is a clinical anesthetic drug and sedative that has also been reported to attenuate inflammatory response, but the mechanisms are not clearly understood. MATERIAL AND METHODS This study investigated the eff...