Cisplatin (CP) is used to treat various tumors. A main restriction of cisplatin nephrotoxicity. This study aimed evaluate the protective effects ZnONPs on cisplatin-induced oxidative stress and rat kidney tissue damage. Eighty adult male Wistar rats (250g-270g) were divided into ten groups: Control (CON), Sham (SH), Bulk ZnO (BZnO), Chemical (ChZnONPs), Green (GrZnONPs), (CP), Cisplatin+BulkZnO...

Objective(s): The current study aimed to assess cisplatin-mediated ovarian apoptosis in a rat model by Royal jelly (RJ). Materials and Methods: Thirty female adult albino rats (180-200 g) were divided into three groups (n=10): saline (0.9% NaCl, IP) was given to the control group, the cisplatin group: received (5 mg/kg/once a week IP) fo...

Introduction: Cisplatin is an anti-cancer drug used in chemotherapy. One of the limiting side effects of cisplatin is decreasing genital gland function, azoospermia and oligospermia. Tribulus terrestris (TT) has been used as an aphrodisiac. The present study amid to investigate the protective effect of TT hydroalcoholic extract against cisplatin-induced apoptisis on testis in mice. Metho...

Background and Objective: Increment in cancer prevalence and subsequent need for chemotherapy leads to distinct kidney-related diseases such as acute kidney injury (AKI). Cisplatin is a common chemotherapeutic agent that has been used in many cancers; however, it can damage renal cells. Capparis spinosa is an important therapeutic plant in Persian medicine that encompasses high amounts of bioac...

Thirty-five Wistar rats weighing 200 - 250 mg were categorized into five treatment groups- the control, saline, cisplatin, pre-cisplatin and post-cisplatin groups, each comprising of seven per group, to assess effects ethanolic leaf extract Newbouldia laevis on cisplatin-induced testicular damage in rats. The control group received feed mash water ad libitum, saline equal volumes physiological ...

dendrobium genus was reported to contain alkaloid, bibenzyl, fluorenone, phenanthrene, sesquiterpenoid, and phenolic acid, which have biological properties. our aim was to investigate the protective effect of an aqueous extract of dendrobium nobile lindl (dne) against cisplatin-induced acute kidney injury (aki). quantification of four phenolic acids (4-hydroxybenzoic, vanillic, syringic, and fe...

Toll-like receptor 4 (TLR4) recognizes bacterial lipopolysaccharide (LPS) and can also be activated by some Group 9/10 transition metals, which is believed to mediate immune hypersensitivity reactions. In this work, we test whether TLR4 the 10 metal platinum platinum-based chemotherapeutic cisplatin. Cisplatin invaluable in childhood cancer treatment but its use limited due a permanent hearing ...

Objective: The clinical use of cisplatin is highly restricted, because of its nephrotoxicity.In this study the protective effect of Nigella sativa (N. sativa) against cisplatin-induced nephrotoxicity was investigated in rats. Materials and Methods: In the current study, the effects of the administration of aqueous-ethanolic extract of N. sativa (100 and 200 mg/kg, BW) and vitamin E (100 mg/kg, ...

Cisplatin is a common chemotherapeutic agent that used for treatment of many solid cancers. Rapid identification of chemotherapy resistance is very important and may lead to effective treatment plan. Spectroscopy techniques, such as infrared spectroscopy, which are sensitive to biochemical composition of samples, have shown potentials to discriminate tissues. Developing in Fourier transform inf...