conclusions gallic acid and csa combination improved antioxidant capacity and cell membrane integrity more than each one alone. therefore, it can be a therapeutic approach to reduce the i/r injury. background myocardial infarction is one of the important causes of death during old ages. gallic acid as an antioxidant or cyclosporine a (csa) as inhibitor of mitochondrial permeability transition p...

introduction: recent studies have shown acute cardioprotective effects of cyclosporine. the aim of the present study was to determine the protective role of cyclosporine on the model simulated the rotational nodal arrhythmia (avnrt) by using extracellular field potential recordings of isolated atrioventricular-node (av-node) of rabbit. methods: this study was performed on isolated double-perfus...

Introduction: Previous studies have indicated a relationship between MPTP pore and AV nodal rate-dependent properties. The aim of present study was to determine acute direct effects of cyclosporine on extracellular field potential of isolated rabbit AV node during experimental atrial fibrillation. Methods: In one group of male New Zealand rabbits (1.5-2.5 kg) cumulative concentrations of cyc...

An analogue 2 of Brasilicardin A, 1 (BraA), a potent immunosuppressive and cytotoxic agent, was synthesized in which the natural tricyclic skeleton was replaced with a synthetically more accessible substituted tetrahydronaphthalene core. BraA, this analogue (BraL), and cyclosporine A were tested for their ability to inhibit the proliferation of human T cells upon CD3/CD28 activation. Although B...

objectives: graft versus host disease (gvhd) is a life threatening reaction in the stem cell transplantation process. nowadays cyclosporine is the most commonly utilized agent for gvhd prophylaxis and it has a major role in successful transplantation. cyclosporine has been applied for many years in this field but it could be stated that currently no general consensus is available for its optima...

background: hormesis is defined as the bio-positive response of something which is bio-negative in high doses. in the present study, the effect of radiation hormesis was evaluated on the survival rate of immunosuppressed balb/c mice by cyclosporine a. materials and methods: we used 75 consanguine, male, balb/c mice in this experiment. the first group received technetium-99m (3700bq) and the sec...