conclusions the present study suggests a beneficial effect of vitamin c adsministration on post-transplant function of the liver from bd liver donors. results no significant differences were observed in mrna expression ratio of il1b and il10 between two groups. despite an acceptable decrease in serum concentration of the inflammatory markers il1b and il10 at time point 2 minus time point 1 (t2-...

Radiation-induced heart toxicity is one of the serious side effects after  a radiation disaster or radiotherapy for patients with chest cancers, leading to a reduction in the quality of life of the patients. Evidence has shown that infiltration of inflammatory cells plays a key role in the development of functional damages to the heart via chronic up-regulation of some pro-fibrotic and pro-infl...

background immune cells and molecules play a vital role in initiating, maintaining, and regulating immunological homeostasis and inflammation in many pathological and physiological processes; however, the changes on expressions and functions of these cells and molecules in hepatitis b virus (hbv) infection has not been elucidated well. conclusions cxcr3-associated chemokines might contribute to...

Cyclophosphamide is a widely used antitumor drug, with induced adverse effects, such as intestinal mucosal injury and immunosuppression. Norcantharidin possesses anticancer activity through enhancement of immunity. We investigated the role norcantharidin in cyclophosphamide-induced Mice were treated cyclophosphamide, exposed to norcantharidin. Enzyme-linked-immunosorbent serologic assay was per...

the present study was designed to investigate the immunomodulatory activity of the ethanolic extract of tinospora cordifolia (family: menispermaceae)stem (climbing shrub, mango plant) at cellular level. for antioxidant study, the liver mitochondria were separated and the concentration of enzymes like lipid peroxidation (lpo), reduced glutathione (gsh), catalase (cat) and superoxide dismutase (s...

Background: During radiation therapy, stromal cells surrounding the tumor (e.g mesenchymal stem cells) may affect the treatment outcomes. We aimed to investigate the effects of gamma radiation on the mRNA expression of cytokines, DNA damage and population doubling time (PDT) of adipose-derived mesenchymal stem cells (ASCs). Material and methods: ASCs were enzymatically extracted from breast tis...

Objective(s) Although, type 2 diabetes is the most frequent type of diabetes, its main cause is yet to be clarified. Several environmental and genetic parameters are believed to be involved in diabetes. It has also been established that cytokines play key roles in pathogenesis of diabetes. Expression of cytokines is different from person to person and in different societies. Several studies sh...