نتایج جستجو برای: dcc
تعداد نتایج: 1899 فیلتر نتایج به سال:
Alterations and defective expression of three putative tumor-suppressor genes, the deleted in colorectal cancer (DCC), p51, and O(6)-methylguanine-DNA methyltransferase (MGMT), have been demonstrated in many cancers. However, it is not known whether the defective expression of each of these genes is independent or whether it reflects a specific methylation abnormality. Here, we investigated the...
یکی از مهمترین ابزار پوشش ریسک نوسانات قیمت بازار نفت خام استفاده از قرارداد آتی میباشد. بنابراین به کمک تصریح رابطه میان سری زمانی قیمتهای نقدی و آتیها میتوان نسبت بهینه پوشش ریسک را محاسبه نمود. از اینرو در این مقاله، از مدلهای OLS، ECM، DCC GARCH و GARCH مبتنی بر کاپولا برای محاسبه و بررسی کارایی نسبت بهینه پوشش ریسک بازار نفت خام طی دوره زمانی 2018-2013 استفاده شده است. نتایج نشان می...
[reaction: see text] Dynamic combinatorial chemistry (DCC) is a promising technique for receptor-aided selection of high-affinity ligands from equilibrating combinatorial libraries. Identification of the specific ligand(s) selected is often challenging, however, due to difficulties associated with chromatographic separation and/or mass degeneracy within the library. Herein, we describe proof-of...
Loss of heterozygosity (LOH) on chromosome 18q21 is found frequently in various human cancers. Three candidate tumor suppressor genes, DCC (deleted in colorectal carcinomas), DPC4 (deleted in pancreatic carcinomas, locus 4), and MADR2/JV18-1 (MAD-related gene 2), have been cloned and identified from this chromosome region. We have reported recently that LOH on chromosome 18q is observed frequen...
Acquired pointmutationswithin the BCR-ABL kinase domain represent a commonmechanismof resistance to ABL inhibitor therapy in patients with chronic myeloid leukemia (CML). The BCR-ABL mutant is highly resistant to imatinib, nilotinib, and dasatinib, and is frequently detected in relapsed patients. This critical gap in resistance coverage drove development of DCC-2036, an ABL inhibitor that binds...
Acquired point mutations within the BCR-ABL kinase domain represent a common mechanism of resistance to ABL inhibitor therapy in patients with chronic myeloid leukemia (CML). The BCR-ABL(T315I) mutant is highly resistant to imatinib, nilotinib, and dasatinib, and is frequently detected in relapsed patients. This critical gap in resistance coverage drove development of DCC-2036, an ABL inhibitor...
Spectral over-smoothing is still observable in the converted spectral envelope when linear multivariate regression (LMR) based spectrum mapping is adopted to convert voice. Therefore, in this paper, we study to place a histogram-equalization (HEQ) module immediately before LMR based mapping and to place a target frame selection (TFS) module immediately after LMR based mapping. These two modules...
این پایان نامه بر اساس مقاله ی ]11[ می باشد و در سه فصل تنظیم شده است. در این پایان نامه بررسی می کنیم که تحت چه شرایطی مدول هایی که در شرط dcc (acc) روی زیرمدول های غیر اساسی صدق می کنند یکنواخت یا آرتینی (نوتری) خواهند بود و ثابت می کنیم که هر مجموع مستقیم متناهی از مدول هایی که در شرط dcc (acc) روی زیرمدول های اساسی صدق می کنند نیز، در شرط dcc (acc) روی زیرمدول های اساسی خود صدق می کند، اما ...
The chemotropic guidance cue netrin-1 mediates attraction of migrating axons during central nervous system development through the receptor Deleted in Colorectal Cancer (DCC). Downstream of netrin-1, activated Rho GTPases Rac1 and Cdc42 induce cytoskeletal rearrangements within the growth cone. The Rho guanine nucleotide exchange factor (GEF) Trio is essential for Rac1 activation downstream of ...
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