Amiodarone (AMD)-induced pulmonary toxicity (AIPT) is the most life-threatening side-effect of AMD treatment. N-Monodesethylamiodarone (DEA), an active metabolite of AMD, also exhibits cytotoxicity and tends to accumulate in the lung more intensively than AMD. In this study, we characterized the mechanism of DEA accumulation using A549 cells as a model of the alveolar epithelium. Typical ATP-de...

In this paper, we discuss the relationship between multi-attribute utility theory and DEA models without explicit inputs (DEA-WEI), including dual models and some theoretical analysis of DEA-WEI models. We then propose generic DEA-WEI models with quadratic utility terms. Finally, we provide illustrative examples to show that DEA-WEI with suitable quadratic utility terms are able to reflect some...

The Effect of Diethanolamine on Hepatic and Renal Phospholipid Metabolism in the Rat. BARBEE, S. J., AND HARTUNG, R. (1979). Toxicol. Appl. Pharmacol. 47,421430. DEA inhibited the in vitro synthesis of both phosphatidyl choline and phosphatidyl ethanolamine in liver tissue. In each caSe the K, was approximately 3 mu DEA. DEA inhibited the formation of phosphatidyl choline competitively, and pro...

The importance of supplier selection is nowadays highlighted more than ever as companies have realized that efficient supplier selection can significantly improve the performance of their supply chain. In this paper, an integrated model that applies Data Envelopment Analysis (DEA) and Support Vector Machine (SVM) is developed to select efficient suppliers based on their predicted efficiency sco...

this study uses the data envelopment analysis (dea) to assess the progress/regression of decision-making units (dmus) having a two-stage structure‎. ‎the progress/regression of these dmu can be assessed in the first stage‎, ‎the second stage‎, ‎and the whole system‎. ‎in the first stage‎, ‎the progress/regression of bank branches in collecting resources and in the second stage their progress/re...

Diethanolamine (DEA) is a common ingredient of personal care products. Dermal administration of DEA diminishes hepatic stores of the essential nutrient choline and alters brain development. We previously reported that 80 mg/kg/day of DEA during pregnancy in mice reduced neurogenesis and increased apoptosis in the fetal hippocampus. This study was designed to establish the dose-response relation...

The efficient management of nursing personnel is of vital importance in a hospital’s environment comprising a vast share of the hospital’s operational costs. In the nurse scheduling problem (NSP), the target is to allocate shifts to the nurses in order to satisfy the hospital’s demand during the planning horizon by considering different objective functions. This paper presents a multi-objective...

For the issue of the lack in plotting analysis method in the research of DEA, this paper introduces a new graphic method—Co-Plot. It can demonstrate DMUs and variables visually in two-dimensional space, and enable the analysis of them at the same time. By applying the ratio relationship among variables, Co-Plot can be combined with DEA in a way to display the results of DEA easily and intuitive...

We developed an alternative approach for measuring information and communication technology (ICT), applying Data Envelopment Analysis (DEA) using data from the International Telecommunications Union as a sample of 183 economies. We compared the ICT-Opportunity Index (ICT-OI) with our DEAOpportunity Index (DEA-OI) and found a high correlation between the two. Our findings suggest that both indic...