Objective(s): Throughout evolution, mammalians have increasingly lost their ability to regenerate structures however rabbits are exceptional since they develop a blastema in their ear wound for regeneration purposes. Blastema consists of a group of undifferentiated cells capable of dividing and differentiating into the ear tissue. The objective of the present study is to isolate, culture expa...

objective(s) the use of co-culture cells as well as extra cellular matrix are among those strategies that have been employed to direct mesenchymal stem cell (msc) bone differentiation in culture. in this regard, there is no study considering the effects of matrigel on mesenchymal stem cell (msc) in vitro bone differentiation. this was the subject of the present study. materials and methods huma...

Sebaceoma is a benign tumor with sebaceous differentiation. It usually presents as a yellowish papule or nodule on the face and scalp. This is a report of a 27-year-old-woman who presented with a giant, 6cm×4.5 cm exophytic tumor on her head. Clinically, we considered several diseases; however, the histological and immunohistochemical features matched those of sebaceoma. The lesion was excised ...

objective: average age of population in the industrial countries has increased. because of aging the percent of the diseases related to the oldness such as multiple myeloma have also increased. it has both common and unique symptoms and effects. the unique effects include wide bone reabsorption. it seems necessary to understand the structure of bone marrow niche and the effects of myeloma cells...

objective: zoledronic acid as a main treatment for osteoporosis has an important role in differentiation of mesenchymal stem cells. however, mechanism of osteoblastic differentiation induction by zoledronic acid is not well understood until now. in this research we evaluate zoledronic acid effect on methylation status of runx2 and dlx5 promoters. materials and methods: after isolation and expa...

objective: growth differentiation factor 9b (gdf9b) is an oocyte-derived growth factor. this protein is essential for the development of ovarian follicles and acts mainly by binding to its receptor on the surface of granulosa cells. the effect of gdf9b on the growth of follicles in various developmental stages, particularly primordial and primary follicles, is unknown. thus the aim of this stud...

in vitro expansion of mesenchymal stem cell (mscs) into large number is necessary for their application in cell-based treatment of articular cartilage defects. on the other hand, some studies have indicated that bio (6-bromoindirubin-3-oxime) possesses mitogenic effects on cell culture. the objective of the present study was to examine the effect of bio on in vitro expansion and chondrogenic di...

context stem cells have the potential to generate a renewable source of cells for regenerative medicine due to their ability to self-renew and differentiate to various functional cell types of the adult organism. the extracellular microenvironment plays a pivotal role in controlling stem cell fate responses. therefore, identification of appropriate environmental stimuli that supports cellular p...