Modern drug discovery demands an integrative approach, using many different technologies, but ultimately based on an understanding of the pathophysiology of the disease state to be treated. Targeting drugs at the main pathophysiological process is the key to success. This issue needs to be addressed with the multiple screening systems available, which can be used to find new leads.

Open science is a new concept for the practice of experimental laboratory-based research, such as drug discovery. The authors have recently gained experience in how to run such projects and here describe some straightforward steps others may wish to take towards more openness in their own research programmes. Existing and inexpensive online tools can solve many challenges, while some psychologi...

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the europeans consider roger bacon as the inventor of spectacles, and the 13th century, as the beginning of using lenses as spectacles. it can truly be said that the lenses had not been born all of a sudden then. it may be concluded that the lenses had been available long before that time.   we are all familiar with quartz, a transparent volcanic stone that begins its journey in the rivers afte...

Training and adaption of employees are time and money consuming. Employees’ turnover can be predicted by their organizational and personal historical data in order to reduce probable loss of organizations. Prediction methods are highly related to human resource management to obtain patterns by historical data. This article implements knowledge discovery steps on real data of a manufacturing pla...