نتایج جستجو برای: disease rat
تعداد نتایج: 1740446 فیلتر نتایج به سال:
Atherosclerosis is arterial wall’s disease initiated by lipid retention, oxidation, and modification, provoking chronic inflmmation ultimately causing stenosis thrombosis. This study investigated the effect of alpha lipoic acid (ALA) on thoracic aorta type 2 diabetic rat. Fifteen adult male rat Rattus novergicus Wistar strain were separated into three groups (n=5), there labelled as control, di...
چکیده ندارد.
Objective: Frankincense improves memory in different models of learning. However, its influence on models of Alzheimer's disease (AD) has not been studied widely. In the present study, the therapeutic effect of frankincense was evaluated in a model of AD induced by i.c.v administration of streptozotocin. Materials and Methods: Under stereotaxic surgery, two guide cannulas were implanted in the ...
Background: Dopaminergic is the most important neurotransmitter is fear. The dopaminergic mesolimbic pathway has essential role in excitable behavior, and it's role in Parkinson disease. The aim of this research in study, the effect of dopaminergic pathway in fear response. Methods: The elevated plus maze was used in combination with the percentage of time spent in the open arms of the maze...
Osteoporosis is a systemic skeletal disease and there is a close relationship between the sympathetic nervous system (SNS) and bone metabolism. Leptin has been shown to regulate bone formation and bone resorption via the SNS. However, the effect of SNS on leptin signaling has not been clearly understood. In the present study, we studied the effect of propranolol on ovariectomy-induced osteoporo...
اضطراب یک پدیده ی پیچیده با علل و نتایج اجتماعی و روانی مهم می باشد. از دیرباز اضطراب و ترس از جمله مباحث مهم روان شناختی بوده و همواره برای کنترل اضطراب راه حل ها و داروهای مختلفی با مکانیسم اثرات متفاوت ارائه شده است. درک مکانیسم دخیل در این رابطه ما را به سمت یافتن داروهای جدیدتر و درمان موثر تر آن هدایت می نماید. در مطالعه ی حاضر، دخالت گیرنده های دوپامینی ناحیه تگمنتوم شکمی (vta) در اثرات ...
هیپوکامپ یکی از مراکز اصلی در فرآیند حافظه و یادگیری است . نقش سیستم اوپیوئیدی در فرآیند حافظه و یادگیری همواره مورد بررسی بوده و از طرفی گیرنده های مربوط به این سیستم ازجمله گیرنده های مو اوپیوئیدی در هیپوکامپ گسترده هستند . در این کار پژوهشی اثر تجویز نالوکسان به عنوان آنتاگونسیت گیرنده های مو اوپیوئید در حضور و عدم حضور کلسترول بر حافظه احترازی غیر فعال مو ش های صحرایی نر بالغ بر مدت زمان تا...
Background and purpose: Parkinson's disease (PD) is a prevalent movement disorder in elderly with progressive motor complications due to antioxidant defense system deficiency and accumulation of degraded proteins in dopaminergic neurons of midbrain. Ginkgolide is biologically active terpenic lactones as a polyphenol, with potent antioxidant and anti-inflammatory properties. The present study ai...
Introduction: Donepezil (DON), an Acetylcholinesterase Inhibitor (AChEI), is widely used in the treatment of Alzheimer’s Disease (AD). The current study aimed at evaluating the effect of donepezil hydrochloride on pyramidal neuron response in CA1 region of a rat model of AD. Methods: In the current experimental study, adult male Wistar rats were randomly divided into four groups: Nucleus Basal...
Osteoporosis is a systemic skeletal disease and there is a close relationship between the sympathetic nervous system (SNS) and bone metabolism. Leptin has been shown to regulate bone formation and bone resorption via the SNS. However, the effect of SNS on leptin signaling has not been clearly understood. In the present study, we studied the effect of propranolol on ovariectomy-induced osteoporo...
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