نتایج جستجو برای: dna damages

تعداد نتایج: 523793  

E Jafari, MH Bahadori Z Salehi

Background Male infertility is a multifactorial syndrome encompassing a wide variety of disorders. In more than half of infertile men, the cause of their infertility is unknown (idiopathic) and could be congenital or acquired. OGG1 is a bifunctional glycosylaseii, in that it has both AP lyase and DNA glycosylase activity and one of its functions is to excise and remove 8-oxo-dGuo from DNA. Amon...

Journal: :journal of paramedical sciences 0
samideh khoei cellular and molecular research centre, medical physics department, school of medicine, iran university of medical sciences, tehran maryam azarian department of biology, north tehran branch, islamic azad university, tehran maryam rafipour department of virology, pasteur institute of iran, tehran

the purpose of this study is to investigate the effects of quercetin as an inhibitor of heat shock proteins and hyperthermia on the induced dna damages and colony formation ability of du145 tumor spheroid culture. du145 cells were cultured as spheroids. on day11, spheroids with mean diameter 100 μm were treated with different concentration of quercetin for 24 hours and then exposed to hyperther...

Journal: :Nature Reviews Microbiology 2010

Journal: :Toxicology research 2013
Tracie Perkins Fullove Hongtao Yu

Polycyclic aromatic hydrocarbons (PAHs), a class of mutagenic environmental contaminants, insert toxicity through both metabolic activation and light irradiation. Pyrene, one of the most widely studied PAHs, along with its mono-substituted derivatives, 1-amino, 1-bromo, 1-hydroxy, and 1-nitropyrene, were chosen to study the effect of substituents on their phototoxicity, DNA damage and repair. B...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2000
B M Sutherland P V Bennett O Sidorkina J Laval

Clustered DNA damages-two or more closely spaced damages (strand breaks, abasic sites, or oxidized bases) on opposing strands-are suspects as critical lesions producing lethal and mutagenic effects of ionizing radiation. However, as a result of the lack of methods for measuring damage clusters induced by ionizing radiation in genomic DNA, neither the frequencies of their production by physiolog...

Journal: :Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) 1994

2011
Wirginia Krzyściak Agnieszka Cierniak Mariusz Kózka Joanna Kozieł

The main goal of the work reported here was to determine the degree of oxidative/alkali-labile DNA damages in peripheral blood as well as in the blood stasis from varicose vein of (chronic venous disorder) CVD patients. Moreover, determination of the impact of Detralex usage on the level of (oxidative) DNA damages in CVD patients was evaluated as well.The degree of oxidative DNA damages was stu...

Journal: :Carcinogenesis 2006
Young-Ju Lee Su-Jung Park Samantha L M Ciccone Chong-Rak Kim Suk-Hee Lee

Mitomycin C (MMC) induces various types of DNA damages that cause significant cytotoxicity to cells. Accordingly, repair of MMC-induced damages involves multiple repair pathways such as nucleotide excision repair, homologous recombination repair and translesion bypass repair pathways. Nonetheless, repair of the MMC-induced DNA damages in mammals have not been fully delineated. In this study, we...

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