نتایج جستجو برای: efflux pump.
تعداد نتایج: 78705 فیلتر نتایج به سال:
Background & Aims: Today, increasing resistance to antibiotics causes serious problems for treatment of patients. The aim of this study was to determine the role of AdeABC efflux pump in the Benzalkonium chloride and Chlorhexidine MIC value with efflux pump inhibitors (1-1-naphthylmethyl-piperazine and phenyl-arginine-β-naphthylamide) in the A.baumanii strains isolated from intensive care ...
Introduction: In the past decade, multidrug-resistant Acinetobacter baumannii has become one of the most critical challenges in treating infected patients. The AdeABC efflux pump is the most important among the various resistance mechanisms. This pump can force various antibiotics and ethidium bromide out of the bacterial cell to the surrounding environment. Methods: In this study, nine A. baum...
Background: Activity of norA efflux pump is one of the antibiotic resistance mechanisms in ciprofloxacin resistant Staphylococcus aureus. In this study, the effect of Artemisia ciniformis extract on reducing the expression of norA efflux pumps gene in ciprofloxacin-resistant Staphylococcus aureus isolates was studied. Materials and Methods: Ciprofloxacin resistant S. aureus isolates, were trea...
staphylococcus aureus causes a wide variety of infections worldwide. methicillin-resistant s. aureus is one of most common causes of nosocomial and community acquired infections. the fluoroquinolones are an important class of antibiotics that used to treat infections caused by s. aureus. today, a significant increase in the rate of ciprofloxacin resistance in methicillin-resistant s. aureus str...
Background and purpose: Acinetobacter spp. is a non-fermentative gram- negative bacterium involving in various nosocomial infections. During last decade increasing number of multidrug-resistant isolates of Acinetobacter spp. have been reported. This type of resistance is possibly related to efflux pumps. This research aimed at identifying the phonotypic and genotypic characteristics of efflux p...
The NorA efflux pump considered as one of the contributors to antibiotic resistance in Staphylococcus aureus strains. One of the challenges of the researchers is finding natural plant compounds with the ability to inhibit the pumps. The aim of this study was to investigate the inhibitory effect of thyme (Thymus vulgaris) extract on NorA efflux pump in ciprofloxacin-resistant strains of S. aureu...
Background and Objective: Antibiotic resistant phenotypes of bacteria have been shown to be related to efflux pumps. Research for finding compounds with an ability to inhibit these pumps seems worthwhile due to their ability to increase bacterial sensitivity to antibiotics or return sensitivity to resistant strains. The aim of this study was to evaluate inhibitory effect of Thymus daenensis ess...
conclusions adeabc efflux system plays a vital role in multidrug resistance in clinical a. baumannii isolates. it was noted that the most important gene responsible for multidrug resistance within this system was the adeb gene especially in carbapenems resistance. methods this study was conducted on 84 multidrug resistant and 13 carbapenem-susceptible a. baumannii isolates obtained from burn an...
Background and Aim: Ciprofloxacin-resistant Salmonella spp. are among the most important causative agents of food-borne infections. The marA efflux pump in this bacterium plays a significant role in the development of drug resistance. The aim of this study was to investigate marA efflux pump gene expression in Ciprofloxacin resistant Salmonella enteritidis clinical strains by Real Time PCR. Mat...
conclusions the efflux pump may play a role in antibiotic resistance in a. baumannii isolates. the ability of a. baumannii isolates to acquire drug resistance by the efflux pump mechanism is a concern. thus, new strategies are required in order to eliminate the efflux transport activity from resistant a. baumannii isolates causing nosocomial infections. background acinetobacter baumannii has em...
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