The genotoxic effect of endosulfan and the modulatory effect of vitamin C in growing albino rats were studied by bone marrow micronucleus assay. Seven days old male Wistar rats were treated with 3, 6, 9, 12mg/kg Endosulfan orally (10 pups/group),for up to 60 days, at intervals of 24h. For 2 more groups (n=10/group), Endosulfan 9mg/kg and 12mg/kg was administered along with vitamin C (20mg/kg). ...

A seasonal field campaign by passive sampling was conducted from February 2008 to February 2009, aiming to measure air concentrations of organochlorine pesticides (OCPs) in the urban and suburban areas in Dalian. At the urban site, similar annual average concentrations of α-endosulfan and α-HCH were found, both being approximately 4 times as high as those of p,p'-DDT and p,p'-DDE, while at the ...

background: the role of oxidative stress in endosulfan-induced reproductive toxicity has been implicated. this study was performed to evaluate the possible protective effect of vitamins e and c, against endosulfan-induced reproductive toxicity in rats. methods: fifty adult male sprague–dawley rats were randomly divided into five groups (n=10 each). the groups included a control receiving vehicl...

Recently use of endosulfan has aroused a great concern among clinical and basic neuroscientists as besides adult population even the children residing in some areas of touristic state of Kerala, India which are under constant spraying of endosulfan had shown symptoms of CNS dysfunctioning including cerebral palsy, retardation of mental and physical growth, epilepsy and various congenital anomal...

Recently use of endosulfan has aroused a great concern among clinical and basic neuroscientists as besides adult population even the children residing in some areas of touristic state of Kerala, India which are under constant spraying of endosulfan had shown symptoms of CNS dysfunctioning including cerebral palsy, retardation of mental and physical growth, epilepsy and various congenital anomal...

Endosulfan is a broad-spectrum cyclodiene insecticide that has been used extensively for over 30 years on a variety of crops. It is a mixture of two stereoisomers, a and b endosulfan, in a ratio of 7 : 3. Its toxicity is extremely high against fish and aquatic invertebrates, and it has increasingly been implicated in mammalian gonadal toxicity, genotoxicity and neurotoxicity; however, endosulfa...

Endosulfan (6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,3,4-benzo(e)dioxathiepin-3-oxide) is a broad-spectrum chlorinated cyclodiene insecticide. This study was performed to elucidate the stereoselective metabolism of endosulfan in human liver microsomes and to characterize the cytochrome P450 (P450) enzymes that are involved in the metabolism of endosulfan. Human liver micro...

Background: The role of oxidative stress in endosulfan-induced reproductive toxicity has been implicated. This study was performed to evaluate the possible protective effect of vitamins E and C, against endosulfan-induced reproductive toxicity in rats. Methods: Fifty adult male Sprague–Dawley rats were randomly divided into five groups (n=10 each). The groups included a control receivin...