نتایج جستجو برای: floating matrix tablets

تعداد نتایج: 398331  

Journal: :iranian journal of pharmaceutical research 0
shailesh prajapati department of pharmaceutics, shri sarvajanik pharmacy college, mehsana, gujarat, india. laxmanbhai. patel department of pharmaceutics, c. u. shah college institute of pharmacy and research wadhwan, gujarat, india. chhaganbhai patel department of pharmaceutics, c. u. shah college institute of pharmacy and research wadhwan, gujarat, india.

the purpose of this research was to prepare a floating matrix tablet containing domperidone as a model drug. polyethylene oxide (peo) and hydroxypropyl methylcellulose (hpmc) were evaluated for matrix-forming properties. a simplex lattice design was applied to systemically optimize the drug release profile. the amounts of peo wsr 303, hpmc k15m and sodium bicarbonate were selected as independen...

سعیدی, مجید, اکبری, جعفر, عنایتی فرد, رضا, چاوشیان, امید,

Background and purpose: The gastroretentive drug delivery systems can be retained in the stomach due to low bulk density. This assist in improving the oral sustained delivery of drugs that have an absorption window in a particular region of the gastrointestinal tract. These systems release the drug content before reaching the absorption site and provide optimal bioavailability. Several approach...

Journal: :iranian journal of pharmaceutical sciences 0
muhammad imran faculty of pharmacy, bhauddin zakaryia university, multan, pakistan. nazar muhammad ranjha faculty of pharmacy, bhauddin zakaryia university, multan, pakistan. rao khurram ayoub faculty of pharmacy, bhauddin zakaryia university, multan, pakistan.

the main objective of the present study was to formulate gastroretentive effervescent sustained release drug delivery systems of risperidone floating tablets with the help of methocel® k15, ethocel® standard 7fp premium, eudragit ® rs100 sustained release polymers to improve its safety profile, bioavailability and patient compliance. risperidone floating tablets were formulated by wet granulati...

Muhammad Imran Nazar Muhammad Ranjha Rao Khurram Ayoub

The main objective of the present study was to formulate gastroretentive effervescent sustained release drug delivery systems of risperidone floating tablets with the help of Methocel® K15, Ethocel® standard 7FP premium, Eudragit ® RS100 sustained release polymers to improve its safety profile, bioavailability and patient compliance. Risperidone floating tablets were formulated by wet granulati...

2009
S. T. Prajapati L. D. Patel D. M. Patel

Floating matrix tablets of domperidone were developed to prolong gastric residence time and thereby increased drug bioavailability. Domperidone was chosen as a model drug because it is poorly absorbed from the lower gastrointestinal tract. The tablets were prepared by wet granulation technique, using polymers such as hydroxypropylmethylcellulose K4M, carbopol 934P, and sodium alginate, either a...

2015
P. T. Gunjal M. B. Shinde V. S. Gharge S. V. Pimple M. K. Gurjar M. N. Shah

The objective of this present investigation was to develop and formulate floating sustained release matrix tablets of s (-) atenolol, by using different polymer combinations and filler, to optimize by using surface response methodology for different drug release variables and to evaluate the drug release pattern of the optimized product. Floating sustained release matrix tablets of various comb...

2012
Ghada E. Yassin Afaf A. Ramadan

Floating matrix tablets of Glimepiride were developed to enhance its bioavailability by prolonging the gastric residence time in which Glimepiride was chosen as a model drug because of its has incomplete absorption due to its low gastric residence time. Floating matrix tablets were prepared using melt granulation technique. Bees wax was used as a hydrophobic meltable material. Hydroxypropylmeth...

Journal: :Acta pharmaceutica 2011
Canan Hasçiçek Günseli Yüksel-Tilkan Berna Türkmen Nurten Ozdemir

Floating dosage forms of acetylsalicylic acid, used for its antithrombotic effect, were developed to prolong gastric residence time and increase bioavailability. In the two-layer tablet formulation, hydroxypropyl methylcellulose (HPMC) of high viscosity and an effervescent mixture of citric acid and sodium bicarbonate formed the floating layer. The release layer contained the drug, direct table...

2015
HUSSAIN MOHAMMED ASIF TADIKONDA RAMA RAO MAIMUNA ANJUM Ranga Reddy

Drugs that have narrow absorption window in the gastro-intestinal tract (GIT) will have poor absorption. For these drugs, gastro-retentive drug delivery systems offer the advantages in prolonging the gastric emptying time. Floating and sustained release tablets are developed by using a combination of hydrophilic polymer (Hydroxypropyl methylcellulose) and effervescent substance (Sodium bicarbon...

Journal: :iranian journal of pharmaceutical research 0
a kulkarni m bhatia

this study was performed to design bilayer regioselective floating tablets of atenolol and lovastatin to give immediate release of lovastatin and sustained release of atenolol. bilayer floating tablets comprised two layers, i.e immediate release and controlled release layers. the immediate release layer comprised sodium starch glycollate as a super disintegrant and the sustained release layer c...

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