PURPOSE To describe the dark-adaptation (DA) functions in subjects with molecularly proven achromatopsia (ACHM) using refined testing conditions with a view to guiding assessment in forthcoming gene therapy trials. METHODS The DA functions of nine subjects with ACHM were measured and compared with those of normal observers. The size and retinal location of the stimuli used to measure DA sensi...

The olfactory bulb (OB), the first center processing olfactory information, is characterized by a vigorous life-long activity-dependent plasticity responsible for a variety of odor-evoked behavioral responses. It hosts the more numerous group of dopaminergic (DA) neurones in the central nervous system, cells strategically positioned at the entry of the bulbar circuitry, directly in contact with...

An ecard of a graph G is a subgraph formed by deleting an edge. A da-ecard specifies the degree of the deleted edge along with the ecard. The degree associated edge reconstruction number of a graph G, dern(G), is the minimum number of da-ecards that uniquely determines G. The adversary degree associated edge reconstruction number of a graph G, adern(G), is the minimum number k such that every c...

M. Ansaruzzaman,* N.A. Bhuiyan,* G. Balakrish Nair,* David A. Sack,* Marcelino Lucas,† Jacqueline L. Deen,‡ Julia Ampuero,§¶ Claire-Lise Chaignat,# and The Mozambique Cholera Vaccine Demonstration Project Coordination Group *Centre for Health and Population Research, Dhaka, Bangladesh; †Ministério da Saude, Maputo, Mozambique; ‡International Vaccine Institute, Seoul, Korea; §Médecins Sans Front...

BACKGROUND Diet is a major factor in the etiology of colorectal cancer, with high fish consumption possibly decreasing colorectal cancer risk, as was shown in several observational studies. To date, no intervention trials have examined the possible beneficial effects of fish intake on colorectal cancer risk. OBJECTIVE The objective was to investigate the effects of a 6-mo intervention with oi...

Computerized dynamic assessment has been proposed as a solution to the practicality issues involved in ordinary dynamic assessment procedures. However, most of computerized dynamic assessment studies have addressed receptive skills (i.e., reading and listening). Responding to the scarcity of CDA studies of productive skills, the present study was an attempt to design and implement a computerize...

J. Depeyrot , G. J. da Silva, C. R. Alves, E. C. Sousa, M. Magalh~ aes, A. M. Figueiredo Neto, M. H. Sousa, and F. A. Tourinho Complex Fluids Group, Instituto de F sica, Universidade de Bras lia, Caixa Postal 04455, 70919-970, Bras lia (DF), Brazil Instituto de F sica, Universidade de S~ao Paulo, Caixa Postal 66318, S~ao Paulo (SP), Brazil Complex Fluids Group, Instituto de Qu mica, Universidad...

Domoic acid (DA) is a neuroexcitatory amino acid that is naturally produced by some marine diatom species of the genus Pseudo-nitzschia. Ingestion of DA-contaminated seafood by humans results in a severe neurotoxic disease known as amnesic shellfish poisoning (ASP). Clinical signs of ASP include seizures and neuronal damage from activation of ionotropic glutamate receptors. However, the impacts...

Cartesian graph bundles is a class of graphs that is a generalization of the Cartesian graph products. Let G be a kG-connected graph and Dc(G) denote the diameter of G after deleting any of its c < kG vertices. We prove that if G1, G2, . . . , Gq are k1connected, k2-connected,. . . , kq-connected graphs and 0 ≤ a1 < k1, 0 ≤ a2 < k2,. . . , 0 ≤ aq < kq and a = a1 + a2 + . . . + aq + (q − 1), the...

Liver transplantation is the standard treatment for end‑stage liver failure; however, rejection can result in allograft failure. In order to investigate the role of Notch 1 during rejection, the present study evaluated Notch 1 expression, as well as the levels of immune reactivity, in rat liver allografts. A heterotopic liver transplantation model was established using Dark Agouti (DA) rats as ...