In metazoan integrin signaling is an important process of mediating extracellular and intracellular communication processes. This can be achieved by cooperation of integrins with growth factor receptors (GFRs). Schistosoma mansoni is a helminth parasite inducing schistosomiasis, an infectious disease of worldwide significance for humans and animals. First studies on schistosome integrins reveal...

Epidermal growth factor (EGF) has been shown to facilitate the in vitro maturation of sheep oocytes, and enhance embryo's capability for further development. However, such kind of molecular mechanism has not yet been elucidated. In the present study, we investigated the effect of EGF-mediated mitogen-activated protein kinases 3 and 1 (MAPK3/1) pathway on in vitro maturation of sheep oocytes. U0...

Background: This study was carried out to evaluate the pattern of reactive oxygen species (ROS) variations during in vitro oocyte maturation and embryo development in sheep, and to investigate whether embryo culture condition and the presence of cell-permeable superoxide dismutase mimetic [Manganese (III) meso-tetrakis (4-benzoic acid) porphyrin (MnTBAP)] can influence ROS pattern. Materials an...

Objective In the present study, the effects of alginate (ALG) concentration and ovarian cells (OCs) on the development and function of follicles were simultaneously evaluated. MaterialsAndMethods In the first step, preantral follicles (100-130 µm in diameter) were mechanically isolated from the ovaries of 2-week-old NMRI mice, encapsulated in the absence or presence of OCs in 0.5, 0.75 and 1% A...

Abstract Study question Can the transfer of aggregated chromosomes (AC) as compared to spindle-chromosome (SCT) reduce mitochondrial DNA (mtDNA) carryover and improve development rates? Summary answer The rate mtDNA after AC was only 0.1%, which much less than that 2.0% SCT. What is known already Nuclear techniques such SCT pronuclear have been applied prevent diseases treat early embryonic arr...

Background: Because of the problems of achieving to mature oocytes, abillity to deliver the oocytes to mature outside of ovaries was a big discovery that somewhat could reduce the risk of ART`s.Because of the low percentage of in vitro oocyte maturation, research for improving the IVM condition and increasing the oocyte maturation rate is to be continued. The aim of this research is the study o...