microglia is the effector cell of the innate immune system in central nervous system (cns). these cells mediate inflammatory responses in injuries. besides external factors, microglial function is also controlled by internal factors, including epigenetic regulations. mechanisms of epigenetic regulation mainly consist of dna methylation, histone modifications and use of non-coding rnas. recent s...

histone deacetylases (hdacs) are the enzymes causing deacetylation of histone and non-histone substrates. histone deacetylase inhibitors (hdis) are a family of drugs eliminating the effect of hdacs in malignant cells via inhibition of hdacs. due to extensive effects upon gene expression through interference with fusion genes and transcription factors, hdacs cause proliferation and migration of ...

spinal cord injury (sci), a common result of car accidents, high-altitude falls and crashes, and other violent injuries is increasing yearly. histone deacetylases (hdac) inhibitors including depakine the main characteristics of the use of anti-inflammatory. the purpose of this investigation is to evaluate the effect of depakine intervention on the acute sci at the chronic phase using functional...

The epigenetic alterations like histone modifications , DNA methylation and others remarkable categories  including nucleosome remodeling and RNA mediated targeting have been strongly investigated  recently .In this way , beside the notable importance of DNA methylation ,the histone modifications are the most important issues in the  tumorogenesis and cancer progression. Moreover...

the epigenetic alterations like histone modifications , dna methylation and others remarkable categories  including nucleosome remodeling and rna mediated targeting have been strongly investigated  recently .in this way , beside the notable importance of dna methylation ,the histone modifications are the most important issues in the  tumorogenesis and cancer progression. moreover, the fluctuati...

Microglia is the effector cell of the innate immune system in central nervous system (CNS). These cells mediate inflammatory responses in injuries. Besides external factors, microglial function is also controlled by internal factors, including epigenetic regulations. Mechanisms of epigenetic regulation mainly consist of DNA methylation, histone modifications and use of non-coding RNAs. Recent s...

Isotherms of the binding of the anthracycIine antibiotic, adriamycin (adriblastin), to DNA histone complexes was studied by means of spectroscopic analysis. The results indicated that: (a) binding of adriamycin to histones reduced the interaction of histones with DNA, (b) binding of the drug to DNA did not change the binding affinity of histone to DNA and, (c) in the explored binding range...

histone acetylation, one of the first and best studied histone post-translational modifications (ptms), as well as the factors involved in its deposition (writers), binding (readers) and removal (erasers), have been shown to act at the heart of regulatory circuits controlling essential cellular functions. the identification of a variety of competing histone lysine-modifying acyl groups includin...