Human Immunodeficiency Virus (HIV) infects human by destroying the immune system. The types of HIV strains HIV-1 and HIV-2, among being more prevalent considered deadly. Eventually either leads to disease Acquired Syndrome (AIDS). Traditional medicinal plants have a pivotal role in modern pharmacological process due their rich composition secondary metabolites with significant biological activi...

Disease progression is slower in HIV-2, as compared with HIV-1 infection, accordance low or undetectable plasma viremia at viral setpoint. However, it unclear why most HIV-2 infected individuals are still risk of developing AIDS. To explore if specific host responses linked to HIV disease severity, we have blood gene expression profiles between seronegative and HIV-1, dually HIV-1/HIV-2 individ...

Abstract Background and Aims: The burden of HIV infection and disease continues to be a major global public health concern all over the world. This study was conducted to measure IgG antibody against EBV viral capsid antigen (EBV-VCA IgG), Herpes Simplex Type1, and 2 to determine the seroprevalence of this infection in HIV-positive population. Materials and Methods: A Cross-sectional st...

lentiviral vectors are promising gene delivery tools capable of transducing a variety of dividing and non-dividing cells, including pluripotent stem cells which are refractory for transduction by murine retroviruses. although there is a growing debate on the safety of lentiviral vectors for gene transfer, in particular for those derived from human immunodeficiency viruses, type one (hiv-1) and ...

In an attempt to identify potential new agents that are active against HIV-1, a series of novel pyridopyrimidine-5-carbohydrazide derivatives featuring a substituted benzylidene fragment were designed and synthesized based on the general pharmacophore of HIV-1 integrase inhibitors. The cytotoxicity profiles of these compounds showed no significant toxicity to human cells and they exhibited anti...

O vírus da imunodeficiência humana do tipo 1 (HIV-1) é o agente etiológico AIDS. As hepatites virais B (HBV) e C (HCV) são infecções comuns em indivíduos HIV-positivos. Um dos fatores genéticos humanos investigados no controle replicação HIV-1 na progressão AIDS a enzima APOBEC3G (A3G). Pesquisas investigam sua ação HBV HCV. A resulta perda de informação genética produção virions defeituosos ci...

human immunodeficiency virus infection / acquired immunodeficiency syndrome (hiv/aids) is a disease pertained to the human immune system. given its crucial role in viral replication, hiv-1 protease (hiv-1 pr) is a prime therapeutic target in aids therapy. in this regard, the dynamic aspects of ligand-enzyme interactions may indicate an important role of conformational variability in hiv-1 pr in...