This article describes the judgements used to interpret evidence in evidence-based medicine (EBM) and health technology assessment (HTA). It outlines the methods and processes of EBM and HTA. Respectively, EBM and HTA are approaches to medical clinical decision making and efficient allocation of scarce health resources. At the heart of both is a concern to review and synthesise evidence, especi...

Microbial amino acid biosynthesis is a proven yet underexploited target of antibiotics. The biosynthesis of methionine in particular has been shown to be susceptible to small-molecule inhibition in fungi. The first committed step in Met biosynthesis is the acylation of homoserine (Hse) by the enzyme homoserine transacetylase (HTA). We have identified the MET2 gene of Cryptococcus neoformans H99...

For the past several years, we have discussed the idea of producing a publication on the history of health technology assessment (HTA). It seemed important to us to develop this history now, while those who lived it can give their own accounts. An exception is Seymour Perry, the first president of ISTAHC and the Director of the first national public program in HTA, the U.S. National Center for ...

All societies face the need to make judgments about what interventions (both public health and personal medical) to provide to their populations under reasonable resource constraints. Their decisions should be informed by good evidence and arguments from health technology assessment (HTA). But if HTA restricts itself to evaluations of safety, efficacy, and cost-effectiveness, it risks being vie...

OBJECTIVES The aim of this study was to describe the history of health technology assessment (HTA) in France. METHODS The approach was a descriptive review done by people who have been very much involved in this history. RESULTS The interest in HTA and evaluation as a tool for health decision making goes back to the 1970s in France. During the 1980s, there were several attempts to develop a...

This research was conducted to organize and model a comprehensive paratransit dispatching task activity in a computer-assisted control room. The dispatching task involves continuous monitoring and interaction with archived and real-time data using a dispatch software. Extensive field observations and video recordings of dispatch operations were conducted. Then, an expert dispatcher was used to ...

Introduction The use of Health Technology Assessment (HTA) in hospitals contributes to decision-making, professional training, greater interaction with technical scientific knowledge, resource-saving, and partnerships. Hospitals are strategic for the field clinical management quality care open partnerships national international agencies groups. Despite hospital-based (HB)-HTA movement, incipie...

Neural processes that support individual differences in trait anxiety and the amount of representations in visual-spatial working memory (WM) are currently unclear. We measured the contralateral delay activity (CDA) in a lateralized change detection task to explore this question. Different levels of memory load were varied within each block. Despite their unimpaired behavioral performance, indi...