background: an explosion of research has been done in discovering how human health is affected by environmental factors. i will discuss the impacts of environmental cancer causing factors and how they continue to cause multiple disruptions in cellular networking. some risk factors may not cause cancer. other factors initiate consecutive genetic mutations that would eventually alter the normal p...

abo blood type antigens are polymorphic, inherited structures presented on the surface of red blood cells. although abo blood group antigens is the most important antigens in transfusion medicine, its main role is not clearly clarified. correlation between abo blood group and susceptibility to certain infectious and non-infectious diseases is a controversial issue. since, lack of blood type ant...

Background: Gastrointestinal (GI) malignancies are the most common cancers and account for nearly half of all cancer-related deaths in Iran. There was a strong association between human papillomavirus (HPV) infection and urogenital cancers, in particular the cervix. However, there is no clear causal relationship in all types of cancers, including gastrointestinal cancers. Therefore, the present...

Precise regulation of signal transduction pathways is crucial for normal animal development and for maintaining cellular and tissue homeostasis in adults. The Wnt/Frizzled-mediated signaling includes canonical and non-canonical signal transduction pathways. Upregulation or downregulation of the canonical Wnt-signaling (or the Wnt/β-Catenin signal transduction) leads to a variety of human diseas...

Cervical cancer is, globally known to be, one of the most common cancers among women especially indeveloping countries. More than 90% of cervical cancers are associated with high-risk humanpapillomaviruses (HPVs) particularly HPV types 16 and 18. Two major strategies have been developed forprevention and treatment of cervical cancer and other HPV-associated malignancies; the first one is based ...

background: gastric and colorectal adenocarcinoma are the second and the fifth most common cancers in iran, respectively. expression of cytokeratin 7 (ck7) is established in most malignancies including gastric and colorectal adenocarcinoma. demonstration of ck7 could be related to prognostic factors and help to the better management of the patients. the objective of our study was to evaluate th...