One of the most common causes of mortality in acute kidney injury is brain dysfunction. Here we investigated the possible protective effect of erythropoietin (EPO) on cognitive impairments induced by bilateral renal ischemia (BRI). Eighty male Wistar rats were allocated into 8 groups: 1, 2) Sham+V (Vehicle), 3, 4) Sham+EPO, 5, 6) BRI+V, 7, 8) BRI+EPO. The groups followed by the reperfusion per...

Background: The aim of this study was to investigate the short term protective effect of oxytocin on testicular ischemia reperfusion injury immediately after detorsion in a rat model. Materials and Methods: Twenty adult rats were randomly divided into four groups: Control, Ischemia- Reperfusion (IR), Oxytocin and IR+ Oxytocin. Testicular ischemia was achieved by torsion of the left testis 720° ...

background: testicular torsion and detorsion causes reperfusion injury which damages the testicular tissue and affects the quality of sperm. deterioration in the quality of sperm worldwide is the recent scenario and one of its reasons is testicular ischemic/ reperfusion (ir) injury. therefore the present study aims at producing new drugs for the treatment of testicular ir injury. methods: 42 an...

Redox balance maintaining is a prerequisite for normal cardiomyocytes metabolism. Reperfusion injury of the heart characterized by an explosive increase in ROS generation, cell membranes damage, dysfunction proteins, development muscle contracture etc. It was shown that hydrogen sulfide (H2S) and precursor its synthesis amino acid L-cysteine provided cardioprotective effect against ischemiarepe...

The aim of this study was to analyse various gene expression profiles of muscle tissue during normoxia, ischaemia and after reperfusion in human muscle free flaps, to gain an understanding of the occurring regulatory, inflammatory and apoptotic processes on a cellular and molecular basis. Eleven Caucasian patients with soft tissue defects needing coverage with microsurgical free muscle flaps we...

BACKGROUND Peroxynitrite generated from nitric oxide (NO) and superoxide (O2-) contributes to ischemia/reperfusion (I/R) injury. Feedback inhibition of endothelial NO synthase by NO may inhibit O2- production generated also by endothelial NO synthase at diminished local L-arginine concentrations accompanying I/R. METHODS AND RESULTS During hindlimb I/R (2.5 hours/2 hours), in vivo NO was moni...

AIMS Uncoupled endothelial nitric oxide synthase (eNOS) is a major contributor to vascular reactive oxygen species generation in ischaemia/reperfusion (I/R) injury. Supplementation of NO by the novel NO donor S-nitroso human serum albumin (S-NO-HSA) may inhibit uncoupling of eNOS (feedback inhibition). METHODS AND RESULTS Pigs (n = 14; 33.1 +/- 1.7 kg) were continuously monitored for heart ra...

Abstract Cerebral ischemia is an extremely complex disease that can be caused by a variety of factors. cause great harm to human body. Sevoflurane volatile anesthetic frequently used in clinic, and has lot advantages, such as quick induction general anesthesia, anesthesia recovery, no respiratory tract irritation, muscle relaxation, small cycle effect. The mechanism sevoflurane preconditioning ...