Insulin-loaded biodegradable chitosan nanoparticle was prepared by the polyelec-trolyte complex formation method. The prepared nanoparticles were in the size of 110 nm and had high entrapment (91.0%) capacity. The transdermal nanoinsulin was characterized by in vivo hypoglycemic effects. Plasma glucose was decreased to the range of 80.34 to 96.74 mg/dl, and insulin levels were in...

Drug-induced cholestasis is the main type of liver disorder accompanied by high morbidity and mortality. Evidence for the role of hepatobiliary pumps in the cholestasis patho-mechanism is constantly increasing. Recognition of the interactions of chemical agents with these transporters at the initial phases of drug discovery can help develop new drug candidates with low cholestasis potential. Th...

the objective of this investigation was the development of chitosan/xanthan polyelectrolyte complex based mucoadhesive nasal insert of promethazine hydrochloride a drug used in the treatment of motion sickness. a 32 factorial design was applied for preparing chitosan/xanthan polyelectrolyte complex and to study the effect of independent variables i.e. concentration of xanthan [x1] and concentra...

background: in vivo dosimetry is a method for estimation of overall error in the delivered dose to the patients at the end of radiotherapy process. in this research, two methods for target dose calculation were evaluated on midline and central axis of photon beams in in vivo dosimetry of thorax fields. materials and methods: entrance and exit doses for anterior and lateral fields of thorax were...

the aim of this study was to optimize the encapsulation conditions of garlic oil (go) with β-cyclodextrin (go/β-cd) inclusion complex by the co-precipitation method. response surface optimization of encapsulation of go with β–cd was performed with a three-variable, three-level and the optimum conditions were as follows: temperature: 35oc, core/wall: 8/100, and wall/solvent: 5.5/100. the complex...