introduction: indomethacin increases generation of mitochondrial reactive oxygen species (ros) which have a crucial role in the indomethacin-induced gastric ulcer. coenzyme q10 has an antioxidant activity on mitochondria and cell membranes and protects lipids from oxidation and is essential for stabilizing biological membranes. superoxide dismutase (sod) acts as one of the defense mechanisms ag...

In the present study, we investigated the effects of histidine and vitamin C (alone or in combination) treatments against isoproterenol (a β-adrenergic receptor agonist)-induced acute myocardial infarction in rats. We used propranolol (a β-adrenergic receptor blocker) to compare the results. Rats were given intraperitoneal injections of histidine (40 mg kg-1) and vitamin C (40 mg kg<...

Paraquat (PQ), is one of the most widely used herbicides all over the world. PQ could induce dopaminergic cell death. Since dopamine involves in memory processing, we investigated the recovery effect of vitamin C on spatial memory along with oxidative stress parameters during PQ induced neurotoxicity in male rats. Rats were divided into five groups (n= 7): control (saline 0.9%), PQ (2.67 and 5 ...

the antioxidant activity of the melia azedarach was investigated in rats with ethanol-induced erythrocyte damage. chronic administration of ethanol (20% w/v, 2 g/kg.p.o.,daily for four weeks) increased the level of lipid peroxidation (lpo), decreased the activity of superoxide dismutase (sod) and catalase and reduced the content of glutathione (gsh). the concurrent treatment of ethanol-administ...

The antioxidant activity of the melia azedarach was investigated in rats with ethanol-induced erythrocyte damage. Chronic administration of ethanol (20% w/v, 2 g/kg.p.o.,daily for four weeks) increased the level of lipid peroxidation (LPO), decreased the activity of superoxide dismutase (SOD) and catalase and reduced the content of glutathione (GSH). The concurrent treatment of ethanol-admini...

Introduction: Indomethacin increases generation of mitochondrial reactive oxygen species (ROS) which have a crucial role in the indomethacin-induced gastric ulcer. Coenzyme Q10 has an antioxidant activity on mitochondria and cell membranes and protects lipids from oxidation and is essential for stabilizing biological membranes. Superoxide dismutase (SOD) acts as one of the defense mechanisms ag...

BACKGROUND : The present study was designed to measure changes in markers of antioxidant capacity (measured individually and total) following acute ischemic stroke. METHODS : The study included 135 subjects. 62 were controls and 73 were ischemic stroke patients diagnosed clinically and by CT scan of the brain. The cases were divided into two groups, The ischemic stroke patients with large vesse...

There is a wealth of epidemiological information on antioxidants and their possible prevention of disease progression but very little of the research on antioxidants has involved intervention studies. In this study, the potential protective effect of vitamin C or E supplementation in vivo against endogenous and H2O2-induced DNA damage levels in lymphocytes was assessed. The supplementation invo...