Rhopalurus junceus scorpion venom has demonstrated high cytotoxic activity in epithelial cancer cells. In the present study, the effect of scorpion venom on cell viability and apoptosis was evaluated in the MDA-MB-231 human breast carcinoma cell line. Cell viability was analyzed using MTT assay. The cell death event was examined trough end-point RT-PCR to identify the expression of apoptosis-re...

The pallid bat (Antrozous pallidus), a gleaning bat found in the western United States and Mexico, hunts a wide variety of ground-dwelling prey, including scorpions. Anecdotal evidence suggests that the pallid bat is resistant to scorpion venom, but no systematic study has been performed. Here we show with behavioral measures and direct injection of venom that the pallid bat is resistant to ven...

There is little information on scorpion stings in Australia. The aim of this study is to describe the circumstances and clinical effects of stings by Australian scorpions. Cases of scorpion stings were collected prospectively from calls and presentations to Australian poison information centres and emergency departments from February 2000 to April 2002. Only definite scorpion stings where the s...

Scorpion venom contains different toxins with multiple biological functions. IMe-AGAP is the first Analgesic-Antitumor like Peptide (AGAP) isolated from Iranian scorpion Mesobuthus eupeus. This peptide is similar to AGAP toxin with high analgesic activity, extracted from Chinese scorpion and inhibits NaV1.8 and NaV1.9 voltage-gated sodium channels involved in the ...

background: scorpion sting is a common medical emergency in iran. the epidemiological features and control of such cases vary from south to north. this review will provide new information about the epidemiology of scorpion stings in different provinces of iran. methods: in this descriptive retrospective study, data on scorpionism including incidence rates, mortality as well as locality from 200...

Scorpion venom is a rich source of toxins which have great potential to develop new therapeutic agents. Scorpion chloride channel toxins (ClTxs), such as Chlorotoxin selectively inhibit human Matrix Methaloproteinase-2 (hMMP-2). The inhibitors of hMMP-2 have potential use in cancer therapy. Three new ClTxs, meuCl14, meuCl15 and meuCl16, derived from the venom transcriptome of Iranian scorpion, ...

Scorpion venom contains different toxins with multiple biological functions. IMe-AGAP is the first Analgesic-Antitumor like Peptide (AGAP) isolated from Iranian scorpion Mesobuthus eupeus. This peptide is similar to AGAP toxin with high analgesic activity, extracted from Chinese scorpion and inhibits NaV1.8 and NaV1.9 voltage-gated sodium channels involved in the ...

This brief review summarizes the studies in systematics and zoogeography of European scorpions. The current “splitting” trend in scorpion taxonomy is only a reasonable response to the former “lumping.” Our better understanding of scorpion systematics became possible due to the availability of new morphological characters and molecular techniques, as well as of new material. Many taxa and local ...

The Cover Feature shows a scorpion amongst colony of A. baumannii bacteria. We can see that the bacteria bear our target pentasaccharide (depicted here using “sugar code” notation) and one these pentasaccharides adorns scorpion′s stinger. this as an apt symbol for role plays in virulence during infection. Nevertheless, we shadow stinger looming ominously over legion baumannii. Might which ensur...