Objective: The dominant driver of arteriogenesis is elevated shear stress sensed by the endothelial glycocalyx thereby promoting arterial outward remodeling. Hyaluronan, a critical component glycocalyx, synthesized 3 HAS isoenzymes (hyaluronan synthases 1-3) at plasma membrane. Considering further importance HAS3 for smooth muscle cell and immune functions we aimed to evaluate its role in colla...

Electron paramagnetic resonance (EPR) spectroscopy was used to record the content of nitric oxide (NO) and copper in brain tissues (frontal lobes hippocampus) liver healthy rats after ischemia modeling. Ischemia simulated by ligation carotid arteries, followed taking 3 ml blood from common artery. Signals triple complexes (DETC) were recorded EPR (DETC)2-Fe2+-NO Cu(DETC)2. Based on direct measu...

Introduction: Anesthetic agents, blood pressure, arterial pH and blood gases have found to influence on the pathophysiology of experimental stroke. Despite, there are very few comparative studies about effects of anesthetic agents in animal model of cerebral ischemia. Therefore, in this study, we investigated the effects of chloral hydrate and pentobarbital anesthesia, as comparative study, on...

global cerebral ischemia (gci) and reperfusion induced apoptosis that lead to cell injury and death. the bax and bcl-2 are pro-apoptotic and anti-apoptotic genes, respectively. these genes belong to the b-cell lymphoma-2 (bcl-2) family.in this study; we assessed the effect of pentoxifylline drug on bax/bcl2 gene dosage expression changes following   ischemic reperfusion injury in kidney. in thi...

Objective: Oxidative stress damages cells and brings about the pathogenesis of ischemia/reperfusion injury. This study was carried out to investigate the preconditioning and cardio protective potential effects of crocin and vitamin E by the eNOS and iNOS express gene in ischemia/reperfusion in rats. Material & Methods: Male rats were divided into seven groups, namely: sham, control group and ex...

Abstract Introduction: Occurrence of cardiac arrhythmias and myocardial infarction are two main deleterious events that are caused by ischemia-reperfusion (IR) injury in the heart. Cardiac preconditioning represents the most potent method of rescuing heart tissue from undergoing irreversible ischemic damage. The aim of the present study was to evaluate oxytocin (OT) cardioprotective effect...

Ovarian torsion is one of the gynecological emergencies that affect ovarian tissue integrity and fertility. In this study, we aim to investigate effects Momordica charantia (MC) on injury induced by ischemia-reperfusion. Twenty-four rats were assigned three groups: control group, ischemia-reperfusion (I/R) group IR + MC group. 600 mg/kg extract given via orogastric route. 3-hour ischemia reperf...

Background: Acute limb ischemia (ALI) is a sudden decrease in leg perfusion that threatens the viability of with symptom onset within 2 weeks. In peripheral artery disease (PAD) conditions, occlusion blood vessels can occur due to thrombosis or atherosclerotic plaque embolism, which called "acute on chronic ischemia". The development endovascular therapy has made this an important role restorin...