PURPOSE To determine the sensitivity and specificity of anterior and posterior corneal elevation parameters as determined by Orbscan II (Bausch and Lomb, Rochester, NY, USA) in discriminating between (sub) clinical keratoconus (KCN) and normal corneas. METHODS This prospective case-control study included 28 eyes with subclinical KCN, 65 with clinical KCN and 141 normal corneas. Anterior and p...

purpose: to determine the incidence and prevalence of clinical keratoconus (kcn) in yazd province. methods: in this population-based survey, a surveillance program was established in yazd province (population size=990,818). all new clinically diagnosed cases of kcn were registered and referred for topographic imaging during one year (2008-2009) by all local ophthalmologist and optometrists. peo...

KCN-1 is known to reduce tumor growth 6-fold in mice implanted with LN229 glioma cells. Although this inhibitor is effective, the mechanism of action for KCN-1 is not well understood. Based on preliminary studies, KCN-1 reduces tumor growth by disrupting the HIF-1 (hypoxia-induced factor-1) pathway. The binding target of KCN-1 needs to be investigated in order to develop KCN-1 or its analogs fo...

Experiments with chloroplasts and purified spinach plastocyanin suggest a mechanism for KCN inhibition of Photosystem I. KCN inhibition can be bypassed by a detergent or reversed by replacement of the inactive plastocyanin. KCN bleaches and inactivates purified plastocyanin. KCN releases copper from chloroplast membranes and from purified plastocyanin. Cyanide does not bind to the apoprotein pr...

purpose: to evaluate topographic corneal changes in relatives of patients with keratoconus (kcn). methods: this study was performed on 300 eyes of 150 relatives of 45 kcn patients. complete slit lamp examination, refraction, and corneal topography was performed on all eyes. the topographic indices for diagnosis of keratoconus was based on rabinowitz criteria. results: the study included 84 (56%...

This study was proposed to investigate the potential protective effect of alpha-lipoic acid (α-LA) against potassium cyanide (KCN)-induced seizures and lethality in mice. The intraperitoneal ED(50) value of KCN, as measured by induction of clonic and tonic seizures was increased by pretreatment of mice with α-LA (25, 50 and 100 mg/kg) intraperitoneally in a dose-dependent manner. Similarly, the...

Brain cytochrome oxidase activity was measured after the in vitro addition of potassium cyanide (KCN) or sodium nitroprusside (SNP). Activity of cytochrome oxidase was sensitive to KCN; however, this activity was unaffected by SNP. In SNP- and KCN-treated animals brain cytochrome oxidase activities were measured. At 3 min after SNP injection, inhibition of the enzymatic activity was the same as...

Introduction: Keratoconus (KCN) is one of the degenerative corneal disorders, which causes impairment in normal visual acuity with a higher prevalence Saudi Arabia. The study aimed to assess awareness and knowledge regarding KCN, its risk factors, management among population. Materials Methods: A survey was conducted using pre-tested validated questionnaire distributed through online platforms....