moslem pregnant women are inclined to fast during the month of ramadan. ketonuria and hypoglycemia are harmful in pregnancy. the aim of this study was to find out whether clinical symptoms and/ or calorie deficiency of fasting pregnant women before eftar (ending of the daily fast) can accurately predict ketonuria and hypoglycemia. in a descriptive study, 185 volunteer fasting pregnant women in ...

Catalytic asymmetric Corey-Chaykovsky epoxidation of various ketones with dimethyloxosulfonium methylide using a heterobimetallic La-Li(3)-BINOL complex (LLB) is described. The reaction proceeded smoothly at room temperature in the presence of achiral phosphine oxide additives, and 2,2-disubstituted terminal epoxides were obtained in high enantioselectivity (97%-91% ee) and yield ( > 99%-88%) f...

The sustainable byproduct catalyzed domino strategy has been performed for the facile synthesis of α-formyloxy and acetoxy ketones via iodination/nucleophilic substitution/hydrolyzation/oxidation sequences from simple and readily available aromatic ketones/unsaturated methyl ketones.

The first examples of the directed, boron-mediated aldol reaction between different ketones are presented. Transformation of a variety of ketones to their corresponding boron enolates with Chx2BCl/Et3N, followed by reaction with acceptor ketones in diethyl ether, and oxidation of the resultant boron aldolate (H2O2, MeOH/pH 7 buffer), provided the aldol addition products. The reaction was most f...

Ketones are one of the most common functional groups, and ketone-containing compounds are essential in both the nature and the chemical sciences. As such, the acidities (pKa) of ketones provide valuable information for scientists to screen for biological activities, to determine physical properties or to study reaction mechanisms. Direct measurements of pKa of ketones are not readily available ...

A novel and convenient copper (II) bromide and 1,8-diazabicyclo[5.4.1]undec-7-ene (DBU) or 1,10-phenanthroline catalysis protocol for the construction of α-alkyl-β-keto sulfones via C(sp(3))-H bond functionalization followed by C(sp(3))-S bond formation between aryl ketones and sodium sulfinates at room temperature has been developed. This method is applicable to a wide range of aryl ketones an...

gem-dihydroperoxides as nearly stable peroxidic derivatives of aldehydes and ketones are known important intermediates in synthesis of anti-malaria drugs. also, because containing high concentration of peroxidic oxygen, recently, some of these compounds have been used as solid, efficient and powerful oxidants in many oxidation organic reactions. generally, these compounds are synthesized via pe...

Ketones have previously shown beneficial effects in models of neurodegenerative disorders, particularly against associated mitochondrial dysfunction and cognitive impairment. However, evidence of a synaptic protective effect of ketones remains lacking. We tested the effects of ketones on synaptic impairment induced by mitochondrial respiratory complex (MRC) inhibitors using electrophysiological...

Functionalized chiral ketones, such as a-amino ketones, bnitro ketones, and their derivatives, are prevalent building blocks and ubiquitous subunits present in natural products and pharmaceutical lead compunds. The synthesis of chiral ketones can be achieved through direct a substitution. For example, the synthesis of a-amino ketones has been developed by Jørgensen and co-workers using an elega...