Background: L1 retrotransposons are the most active mobile DNA elements in human genome. Unregulated L1 retrotransposition may have deleterious effect by disrupting vital genes and inducing genomic instabilities. Therefore, human cells control L1 elements by silencing their activities through epigenetic mechanisms. It has been shown that cell division and heavy metals stimulate the frequency of...

background: l1 retrotransposons are the most active mobile dna elements in human genome. unregulated l1 retrotransposition may have deleterious effect by disrupting vital genes and inducing genomic instabilities. therefore, human cells control l1 elements by silencing their activities through epigenetic mechanisms. it has been shown that cell division and heavy metals stimulate the frequency of...

background & aim: chorisia is an important bombacaceous plant that is traditionally used for a variety of ailments. due to its richness in several bioactive phytocompounds, some chorisia species showed a wide range of important biological effects. accordingly, the present work was undertaken to comparatively evaluate the antioxidant potential and effects on adipogenesis of chorisia chodatii...

  Objective(s):  Infection by high-risk papillomavirus is regarded as the major risk factor in the development of cervical cancer. Recombinant DNA technology allows expression of the L1 major capsid protein of HPV in different expression systems, which has intrinsic capacity to self-assemble into viral-like particles (VLP). VLPS are non-infectious, highly immunogenic and can elicit neutralizing...

Background: Mesenchymal stem cells are non-hematopoietic stromal cells that are used in the treatment of many chronic and autoimmune diseases by modulating the immune system. Due to the limitations of using autologous mesenchymal stem cells, the use of allogeneic stem cells is a promising therapeutic approach in the treatment of immunological disorders. This study aimed to investigate the abili...

Background: Programmed cell death protein-1 (PD-1)/PD-L1 pathway is one of the immune checkpoint pathways involved in regulation of the immune responses and suppression of anti-tumor defense. PD-1/B7-H1-blocking antibodies improve immune responses such as cytotoxic activity of CD8+/CD4+T cells and also increase mortality of tumor cells; however their use is accompanied by adverse effects in pat...

objective(s):  infection by high-risk papillomavirus is regarded as the major risk factor in the development of cervical cancer. recombinant dna technology allows expression of the l1 major capsid protein of hpv in different expression systems, which has intrinsic capacity to self-assemble into viral-like particles (vlp). vlps are non-infectious, highly immunogenic and can elicit neutralizing a...

  Objective(s): To investigate the expression of human papilloma virus (HPV) L1 capsid protein, and human telomerase RNA component (hTERC) in cervical cancer and the role of detection of both genes in screening of cervical cancer.   Materials and Methods: A total of 309 patients were recruited and cervical exfoliated cells were collected. Immunocytochemistry was employed to detect HPV L1 capsid...

objective(s): to investigate the expression of human papilloma virus (hpv) l1 capsid protein, and human telomerase rna component (hterc) in cervical cancer and the role of detection of both genes in screening of cervical cancer.   materials and methods: a total of 309 patients were recruited and cervical exfoliated cells were collected. immunocytochemistry was employed to detect hpv l1 capsid p...