introduction valproic acid (vpa, valproate) is an eight-branch fatty acid and varies from other antiepileptic drugs. vpa use might lead to mild to severe hepatotoxicity. the aim of this study was to investigate valproic acid impact on liver transaminases at the beginning of vpa treatment and after three and six months of it. materials and methods this study was designed as a cross sectional pro...

background: occupational lead poisoning is common in workers of some industries, but lead hepatotoxicity has rarely been reported. several animal studies have revealed lead induced liver damage but clinical studies concerning the manifestations of lead induced liver toxicity in humans are scares. this study was designed to investigate the clinical manifestations and pathological parameters of h...

Fatty liver disease is one of the most common diseases in women with type II diabetes. While regular exercise can decrease the complication of this disease, it was not clearly identified. The aim of this study was to evaluate the effect of four weeks aerobic training on Liver Transaminases and some glycemic markers in women with type II diabetes.Materials and Methods: In this study, 20 patients...

Introduction Valproic acid (VPA, Valproate) is an eight-branch fatty acid and varies from other antiepileptic drugs. VPA use might lead to mild to severe hepatotoxicity. The aim of this study was to investigate valproic acid impact on liver transaminases at the beginning of VPA treatment and after three and six months of it. Materials and Methods This study was designed as a cross sectional pro...

the present study has been directed to investigate ursodeoxycholic acid (udca) effect in children, to reduce the high liver transaminases induced by anticonvulsant drugs (drug induced hepatitis). this idea has been driven from cytoprotective and antioxidant properties of udca to be used in drug induced inflammation in liver. twenty two epileptic patients aged between 4 mo - 3 yr whom were under...

background the current organ shortage has prompted the use of marginal organs. we conducted this retrospective study to present our experience with transplanting deceased donor livers with elevated levels of serum transaminases and to explain whether elevated levels of serum transaminases in donors affect allograft function and survival of the recipients. methods data of deceased donor livers a...

Medications currently available for the treatment of hepatitis B virus (HBV) infection are highly effective but not curative. The current paradigm is to recognize patients who require long-term treatment (with its inconveniences) among the majority of healthy carriers who do not need treatment. International guidelines have been established to identify patients requiring treatment but differenc...

Less than 25% of asymptomatic adults have elevated levels of transaminases on a first evaluation, one third of these patients have normal values on a retest. From those who have elevated ALT on retest, some prove to suffer from an acute liver disease (with normal ALT in less than 6 months), and the others represent the category of chronic (more than 6 months) elevation of transaminases. The eti...

The hepatoprotective effect of Annona muricata and Polyalthia cerasoides (Annonaceae) were monitored by estimating the serum transaminases (SGOT and SGPT), serum alkaline phosphatase (SALP), liver and brain lipid peroxidation (LOP) and their total protein content. Both drugs at a dose of 100 μg/kg significantly prevented the increase in serum transaminases, SALP, liver and brain LOP and decreas...