Involvement of LST-1 (a human liver-specific transporter, also called OATP2) as the major transporter in the uptake of pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, by human liver was demonstrated. The hepatic uptake of pravastatin evaluated using human hepatocytes was Na(+)-independent and reached saturation with a Michaelis constant (K(m)) of 11.5 +/- 2.2 microM. T...

Global climate change and increasing urbanization worldwide intensify the need for a better understanding of human heat stress dynamics in urban systems. During heat waves, which are expected to increase in number and intensity, the development of urban cool islands could be a lifesaver for many elderly and vulnerable people. The use of remote sensing data offers the unique possibility to study...

QUESTION UNDER STUDY How do actual aspects of forgoing life supporting therapy (LST) in newborn infants compare with national ethical directives in a Swiss intensive care unit? METHODS A prospective set of data on deaths after forgoing LST over a three year period in a single intensive care unit is analysed in view of the directives issued by the Swiss Academy for Medical Sciences (SAMS). R...

A large number of waterand climate-related applications, such as drought monitoring, are based on spaceborne-derived relationships between land surface temperature (LST) and the normalized difference vegetation index (NDVI). The majority of these applications rely on the existence of a negative slope between the two variables, as identified in siteand time-specific studies. The current paper in...

Spatially continuous satellite infrared temperature measurements are essential for understanding the consequences and drivers of change, at local and regional scales, especially in northern and alpine environments dominated by a complex cryosphere where in situ observations are scarce. We describe two methods for producing daily temperature fields using MODIS ―clear-sky‖ day-time Land Surface T...

Central questions in regenerative biology include how stem cells are maintained and how they transition from self-renewal to differentiation. Germline stem cells (GSCs) in Caeno-rhabditis elegans provide a tractable in vivo model to address these questions. In this system, Notch signaling and PUF RNA binding proteins, FBF-1 and FBF-2 (collectively FBF), maintain a pool of GSCs in a naïve state....

Spatially and temporally resolved observations of near-surface air temperatures (Ta, 1.5–2 m above ground) are essential for understanding hydrothermal circulation at the land–atmosphere interface. However, the uneven spatial distribution of meteorological stations may not effectively capture the true nature of the overall climate pattern. Several studies have attempted to retrieve spatially co...

In this study Yan'an City, a typical hilly valley city, was considered as the study area in order to explain the relationships between the surface urban heat island (SUHI) and land use/land cover (LULC) types, the landscape pattern metrics of LULC types and land surface temperature (LST) and remote sensing indexes were retrieved from Landsat data during 1990-2015, and to find factors contribute...