نتایج جستجو برای: mTORC1
تعداد نتایج: 3845 فیلتر نتایج به سال:
Significance In numerous models of neurodevelopmental disorders and epilepsy, genetic mutations associated with enhanced mTORC1 activity engender an increase in the susceptibility to epileptic seizures. This study shows that deletion mTORC1-downstream translational repressor, 4E-BP2, but not 4E-BP1, promotes epileptogenesis. By deleting 4E-BP2 different cell types, we reveal up-regulation mTORC...
Objective: The purpose of this study was to investigate the effect of 12 weeks aerobic training on the expression of AKT1 and mTORc1 genes in the left ventricle of T2DM rats. Materials and Methods: The statistical sample consisted of 21 male wistar rats from the Pasteur Institute in Tehran. (10 weeks old weighing 220 ± 20 grams). They were divided into three groups: diabetic aerobic training, ...
Background and Objectives: High intensity interval trainings (HIIT) are effective in the physiological cardiac hypertrophy and in reducing the complications of diabetic cardiomyopathy. Therefore, the purpose of this study was to determine the effects of 12 weeks high intensity interval training on the expression of AKT1(Protein Kinase B) and mTORc1)mammalian target of rapamycin( genes in the le...
Targeting mTORC1 has been thoroughly explored in cancer therapy. Following encouraging preclinical studies, mTORC1 inhibitors however failed to provide substantial benefits in cancer patients. Several resistance mechanisms have been identified including mutations of mTOR and activation of alternate proliferation pathways. Moreover, emerging evidence discloses intratumoral heterogeneity of mTORC...
Background: The mTORC1 pathway is one of the important pathways for protein synthesis in the heart, which can lead to physiological or pathological hypertrophy. Diabetes can lead to defects in this pathway. The aim of this study was to examine the effect of 4 weeks’ aerobic training on the content of mTORC1 signaling pathway proteins in heart tissue of type 1 diabetes rats. Methods: In this ...
Background mTORC1 marker pathway is one of the crucial pathways for the regulation of transcription level and an essential route involved in protein synthesis in skeletal muscles. Objective This study aimed to investigate the effect of endurance training on mTORC1 marker pathway in soleus muscle of type 2 diabetic rats. Methods In this experimental study, 16 Sprague-Dawley male rats (Mean±SD ...
Objective: Although type 2 diabetes is a multifactorial illness, one of the major risk factors is the prevalence of obesity.In this context, recent genetic studies on diabetics or pre-diabetics, have shown that some of the newly-known genes make the conditions for type 2 diabetes even in the absence of obesity. One of these genes is called mTORC1, which plays an important role in the synt...
Mammalian target of rapamycin complex 1 (mTORC1) controls growth and survival in response to metabolic cues. Oxidative stress affects mTORC1 via inhibitory and stimulatory inputs. Whereas downregulation of TSC1-TSC2 activates mTORC1 upon oxidative stress, the molecular mechanism of mTORC1 inhibition remains unknown. Here, we identify astrin as an essential negative mTORC1 regulator in the cellu...
Mechanistic target of rapamycin complex 1 (MTORC1) and polo like kinase 1 (PLK1) are major drivers of cancer cell growth and proliferation, and inhibitors of both protein kinases are currently being investigated in clinical studies. To date, MTORC1's and PLK1's functions are mostly studied separately, and reports on their mutual crosstalk are scarce. Here, we identify PLK1 as a physical MTORC1 ...
The mTORC1 kinase promotes growth in response to growth factors, energy levels, and amino acids, and its activity is often deregulated in disease. The Rag GTPases interact with mTORC1 and are proposed to activate it in response to amino acids by promoting mTORC1 translocation to a membrane-bound compartment that contains the mTORC1 activator, Rheb. We show that amino acids induce the movement o...
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