Objective(s): Various microRNAs (miRNAs) are expressed during development of mammalian cells, when they aid in modulating gene expression by mediating mRNA transcript cleavage and/or regulation of translation rate. miR-191 and miR-451 have been shown to be critical regulators of hematopoiesis and have important roles in the induction of erythroid fate decision. So, the aim of this study is inve...

Dear Editor, A key event in the preparation for pregnancy is the differentiation of human endometrial stromal cells (hESCs) into epithelioid decidual cells. This process, termed decidualization, is initiated in the stromal cells of the superficial endometrial layer 9 days after ovulation. Upon decidualization, hESCs acquire the ability to resist oxidative stress, to modulate immune responses to...

Dear Editor, A key event in the preparation for pregnancy is the differentiation of human endometrial stromal cells (hESCs) into epithelioid decidual cells. This process, termed decidualization, is initiated in the stromal cells of the superficial endometrial layer 9 days after ovulation. Upon decidualization, hESCs acquire the ability to resist oxidative stress, to modulate immune responses to...

background:   objective: to understand the changes of mirnas in endometriosis.   materials and methods: with real-time rt-pcr, we investigated the mir-143 and mir-145 expression in eutopic (eu, n=2) and ectopic endometrium (ec, n=11) (from women with endometriosis) (as well as eu+ec, n=11), along with the normal endometrium (en, n=22) (from women without endometriosis, but with leiomyoma). resu...

Background: Chronic lymphocytic leukemia (CLL) is the most common adult human leukemia. Studies revealed that microRNAs (miRNAs) can function as oncogenes or tumor suppressors in CLL and that the expression of miRNAs, such as miR-193b-3p and miR-376a-3p change in several diseases. We aimed to elucidate the changes in miR-193b-3p and miR-376a-3p expression in CLL and determine their potential as...