In this study, we aimed to determine VEGFR-2, EGFR and PDGFR-β tyrosine kinase inhibitory activities of some pyrrolo[2,3-d]pyrimidine derivatives previously synthesized and showed potent cytotoxic and apoptotic effects against several cancer cell lines by our group and to evaluate the relationships between inhibitory activities and binding properties of the active compounds by molecular docking...

ABSTRACT: Quantitative structure-activity relationship (QSAR) study on the piperidone-grafted mono- and bis-spirooxindole-hexahydropyrrolizines as potent butyrylcholinestrase (BuChE) inhibitors were carried out using statistical methods, molecular dynamics and molecular docking simulation. QSAR methodologies, including classification and regression tree (CART), multiple linear regression (MLR),...

background: feline hemotropic mycoplasmas are parasites of erythrocytes and include three species, mycoplasma haemofelis, candidatus mycoplasma haemominutum and candidatus mycoplasma turicensis. diagnosis of the infection with these microorganisms can be carried out using conventional assays such as blood cytology. however, these assays have a low accuracy and a high rate of false-positive resu...

Down syndrome is one of the most common causes of mental retardation observed in approximately 1/700 live birth. The use of two or more STR markers related to chromosome 21 facilitates the diagnosis of Down syndrome within about six hours from the collection of the samples. This is the first study has been performed in Iranian population to assess the diagnostic value of using small tandem repe...

Members of Nemacheilidae Family, Turcinoemacheilus genus were subjected to molecular phylogenetic analysis in this study. This genus was reported in 2009 to inhabit in Karoon River drainage, in contrary to previous assumption that it was the endemic species in the Basin of Tigris River. It was sampled from three stations placed in different tributaries in Karoon drainage and evaluated to unders...

Some organic molecules can be isomerized upon photoirradiation and when accompanied by a change in the visible absorption spectrum, it is called photochromism. Azobenzenes are important part of molecular machines and nanotechnology, Which are This phenomenon is called photoisomerization Azobenzene (azo) chromophores , and have been incorporated into a wide variety of materials and molecular arc...

abstract soybean (glycine max) is an important crop plant which contains a high amount of oil and protein. to evaluate the genetic diversity of 45 soybean genotypes growing in iran, two types of molecular markers (rapd and isj) were used. two sets of different primers were used to compare potential differentiation power of it (intron targeting) and et (exon targeting) primers. data obtained fro...

the sulfur regulatory circuit of the filamentous fungus, neurospora crassa, consists of a set of unlinked structural genes which encode sulfur catabolic and two major regulatory genes which govern their expression. the cys-3 regulatory gene encode a transacting regulatory protein which activates the expression of cys-14 and ars, whereas the other regulatory genes scon-l and scon-2 appear to act...