نتایج جستجو برای: morphine dependence
تعداد نتایج: 171055 فیلتر نتایج به سال:
Kindling is a very suitable animal model for studying basis mechanisms of epilepsy. In this model , repeated exposure to weak electrical or chemical increases neuronal excitability and there fore decreases the threshold for induction of epileptic seizures. According to abundant distribution of opioid peptides and their receptors in different brain structures and also the role of these receptors...
Background and Aims: The opioid system plays a key role in opioid tolerance and dependence. On the other hand, they have shown that the opioid system plays a role in the analgesic effects of Ferula gummosa extract. Therefore, the aim of the present study is to investigate the effect of Ferula gummosa essential oil (FGEO) on morphine tolerance and dependence in mice. Materials and Methods: In t...
Pain associated-anxiety induced by formalin, which resulted in a significant delay in the development of tolerance to morphine antinociception, failed to prevent the development of physical dependence as evidenced by naloxone challenge. Dependence also developed in mice rendered tolerant to morphine. Thus, the development of morphine dependence was observed in the absence and presence of tolera...
Background: Today opioids are used to control and relieve acute and chronic pain. However, the incidence of both tolerance and dependence phenomena are the two major problems in the people who take these drugs. So, in this study the combination effect of haloperidol and methadone on the acquisition and expression of morphine dependence and tolerance have been examined. Methods: In thi...
Background and Objective: According to the problem of dependence and tolerance in addicted patients, the inefficiency of existing treatments and the new sciences recommendation of drug combination therapy for diseases in modern pharmacology, the present study examined the effects of methadone and valproate combination on morphine tolerance and dependence. Materials and Methods: Nine...
Background and Objectives: Despite the analgesic effects of morphine, its chronic use leads to tolerance and dependence, and duloxetine can change the rate of dependence and tolerance. This study aimed to investigate the effect of duloxetine on morphine-induced dependence and tolerance to its analgesic effects in mice. Materials and Methods: In the present experimental study, male mice were ra...
Abstract Background and Objective: According to the issue of dependence and tolerance in addicted patients, the inefficiency of existing treatments and the new recommendation for drug combination therapy for diseases in modern pharmacology, the present study examined the effect of methadone and valproate combination on morphine dependence and tolerance. Materials and Methods: Ninety-eight male ...
BACKGROUND Exercise deprivation has been concluded to have some negative effectson psychological well-being. This study was conducted to find outwhether exercise deprivation may lead to morphine dependence in rats. METHODS Forty male Wistar rats weighing 162 ± 9 g were housed in clear plasticcages in groups of two under standard laboratory conditions. The studyhad two phases. In phase I, the ...
Opioids are powerful pain relievers, but also potent inducers of dependence and tolerance. Chronic morphine administration (via subcutaneous pellet) induces morphine dependence in the nucleus accumbens, an important dependence region in the brain, yet the cellular mechanisms are mostly unknown. Toll-like receptor 2 (TLR2) plays an essential function in controlling innate and inflammatory respon...
1) chronic administration of morphine hydrochloride in the drinking water of mice induced physical dependence. jumping and diarrhea, two signs of withdrawal, were produced by intraperitoneal (ip) injection of naloxone. 2) baclofen, bicuculline and picrotoxin decreased the number of mice's jumping episodes and frequency of diarrhea. 3) muscimol decreased jumping but not diarrhea. 4) the data ind...
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