Acrylamide (ACR) has been classified as a neurotoxic agent in animals and humans. Melatonin (MT) has been shown to be potentially effective in preventing oxidative stress related neurodegenerative disorders. In this study, whether MT exerted a protective effect against ACR-induced oxidative damage was investigated. Results in cells showed that reactive oxygen species (ROS) and malondialdehyde (...

Adult female of Araneus yoshitomii Yoshida 2014 has been described for the first time. The conspecific pair male and specimens was confirmed by DNA barcoding using mt-COI partial sequencing data.

Reduced calorie intake (RCI) suppresses mouse mammary tumor virus (MMTV) transcription and reduces mammary tumor (MT) incidence in Oil/On mice. Since efficient retroviral expression requires cell division, we investigated whether the suppression of MMTV and MT by RCI reflects changes in mammary histogenesis and lowered epithelial kinetics. Prolactin (PRL) augments MMTV transcription. Since PRL ...

We present the complete mitochondrial (mt) genome of Gyrodactylus thymalli, a monogenean ectoparasite on grayling (Thymallus thymallus). The circular genome is 14788 bp in size and includes all 35 genes recognized from other flatworm mt genomes. The overall A+T content of the mt genome is 62.8%. Twenty regions of non-coding DNA ranging from 1 to 111 bp in length were identified in addition to 2...

Forty per cent of patients with mitochondrial myopathies, a diverse group of multisystem diseases predominantly affecting skeletal muscle and the brain, have large deletions of a proportion of muscle mitochondrial DNA (mt DNA). These appeared to be identical in 13 of 28 cases, contained within the region 8286-13595 bp. Analysis of the deletion junction in two cases showed a 13 nucleotide sequen...

The metallothionein (MT) system has been used to analyze the structural features associated with the control of gene expression (1). A pre-requisite for this type of analysis is knowledge of the primary DNA sequence. We have isolated a clone containing the Chinese hamster MT I gene from a Charon 4A EcoRI total digest prepared from a Chinese hamster cell line amplified for the MT genes (XCH 4A-H...

The effects of repeated mild stress on DNA and lipid metabolic damages in multiple organs of dyslipidemic mice, and the preventive role of metallothionein (MT) were investigated. Female adult wild-type and MT-null mice fed high-fat diet (HFD) or standard diet (STD) were repeatedly subjected to fasting or restraint for three weeks. The liver, pancreas, spleen, bone marrow and serum samples were ...

The short tandem repeat (STR) polymorphisms are highly useful tools for personal identification and paternity testing in forensic practice. Sequence analysis of mitochondrial DNA (Mt DNA) is being used to characterize forensic biological specimens, particularly when there is insufficient nuclear DNA in samples for typing. Bones, teeth and other samples that are severely decomposed may be subjec...