Sir, Myocardial perfusion imaging using single-photon emission computed tomography (SPECT) is the most commonly applied diagnostic imaging modality in patients with suspected coronary artery disease in the US, with more than 9 million procedures performed annually. The positive predictive value of SPECT is limited, and in a considerable number of patients with suspected perfusion deficits conve...

The purpose of this study was to validate a semiautomatic method for quantitating the size of relative myocardial perfusion defects from single-photon emission computed tomographic (SPECT) images. We compared the size of the image defect in vivo, expressed as percent of involved left ventricle, as determined by this method with the anatomic size of the defect in vitro in 19 dogs. To test the me...

atients with type 2 diabetes mellitus (DM) have a higher risk of cardiovascular events and death than those without the disease.1–6 Coronary artery disease (CAD) in diabetic patients is frequently silent.7–9 To maximize the effective treatment of cardiovascular disease in patients with DM, it is important to objectively identify CAD in asymptomatic subjects in a noninvasive way as early as poss...

OBJECTIVE The aim of this study was to investigate the most robust predictor of myocardial viability among stress/rest reversibility (coronary flow reserve [CFR] impairment), (201)Tl perfusion status at rest, (201)Tl 24 hours redistribution and systolic wall thickening of (99m)Tc-methoxyisobutylisonitrile using a dual isotope gated myocardial perfusion single-photon emission computed tomography...

It is difficult to assess the likelihood of perioperative cardiac events mainly because of complicated interrelationships between clinical risk and type of surgery. To overcome this problem, The American College of Cardiology/American Heart Association(ACC/AHA)Task Force published guidelines for perioperative cardiovascular evaluation for non-cardiac surgery. The guidelines offer the strategy o...

Abstract Myocardial bridging (MB) is a congenital anomaly characterized by intramyocardial coronary course that can cause compression during systole and lead to myocardial ischemia. The improvement in computed tomography (CT) scanner technology has increased the detection of MB coronary–CT (cCT) exam but assessment their functional significance often challenging. Tha stress–rest perfusion imagi...

Introduction: We aimed to investigate the effect of right bundle branch block (RBBB) on perfusion and functional parameters in dipyridamole stress/rest Tc99m-MIBI gated myocardial perfusion SPECT (GSPECT) which may be helpful in interpretation of myocardial perfusion imaging. Methods: We studied 73 patients with low pre-test likelihood of coronary artery disease in two groups: 38 patients with ...

Introduction: Many patients have only diastolic dysfunction without any abnormality in systolic function. We compared cardiac diastolic parameters obtained by gated myocardial perfusion SPECT (Gated SPECT) with those evaluated by echocardiography. Methods: Forty-nine patients (aged 37-85 years, 19 males and 30 women) underwent Gated SPECT and echocardiogr...

UNLABELLED Assessment of small-animal cardiac data acquired using SPECT requires an accurate understanding of the reproducibility and the uncertainties associated with the technique. Furthermore, it is also useful to have a baseline of reference data against which to compare the outcome of a particular study. METHODS We scanned both healthy and post-myocardial infarction rats injected with (9...

OBJECTIVE To assess the prevalence of myocardial viability by technetium-99m (Tc-99m)-tetrofosmin/fluorine-18-fluorodeoxyglucose (FDG) single photon emission computed tomography (SPECT) in patients with ischaemic cardiomyopathy. DESIGN A retrospective observational study. SETTING Thoraxcenter Rotterdam (a tertiary referral centre). PATIENTS 104 patients with chronic coronary artery diseas...