introduction: influenza can cause more severe diseases and higher rate of morbidity and mortality in the elderly population. therefore, they should receive influenza vaccine annually. however, the host response to vaccine is less in older individuals. on the other hand, selenium can act as a stimulator of the immune system and cause increased immunity and response to vaccine. this study was car...

According to the reports of WHO, stability of Rev.1 vaccine should take more than one year, while the expiring date for the vaccine produced in Iran is 3 to 4 months, therefore any attempt to elongate the stability of this vaccine can solve many problems of the production including the request of Veterinary Organization of Iran in this regard. The objective of this study was to increase the sta...

Background: Recent studies indicate an increased incidence of pertussis disease in recent years. The aim of this study was to evaluate the efficacy of the acellular vaccine for children (as a replacement of current whole cell vaccine in the Expanded Program on Immunization) and for high-risk adults in Iran through updating current best available evidence.   Methods: We performed a syste...

  For evaluation the stability and potency of anthrax vaccine prepared in Razi Vaccine and Serum Research Institute in Iran, samples of different batches of vaccine were kept at 4-8 °C (refrigerator), 20-25 °C (room temperature) and 37 °C (incubator).The viable spores/ml of vaccines were determined using plate–counting method before and after holding at different temperatures monthly. Vaccine p...

context tuberculosis (tb) disease caused by mycobacterium tuberculosis (mtb) remains as one of the leading infectious causes of death and disease throughout the world. the history of tuberculosis as a worldwide fatal illness traces back to antiquity, being a well-known disease in ancient civilizations. evidence acquisition presented here, is a brief review of the history of tuberculosis and bac...

An inactivated trivalent fowl cholera vaccine consisted of serotypes 1, 3 and 4 Pasteurella multocida strains was prepared. The vaccine provided 70-100% protection against challenge with homologous starins. ELISA assay showed a considerable increase in antibody titer after towice vaccination of 8 weeks chickens. It was found that the trivalent vaccine can induce immunogenic response in vaccinat...

Background: Due to high genetic variation in human leukocyte antigen )HLA( alleles, epitope-based vaccines don’t show equal efficacy in different human populations. therefore, we proposed a multi-epitope vaccine against SARS-CoV-2 for Iranian populations. Materials and Methods: For this purpose, the proteins without allergenicity and high antigenicity as well as conservancy level from SARS-CoV...

Frequent vaccination failures have occurred in the broiler farms in Eurasian countries during Newcastle disease outbreaks. The disease is enzootic in many countries of the region, especially in southwest Asia. I-2 vaccine has been used successfully in village chickens in many Asian and African countries. Our preliminary study showed good efficacy of the vaccine in broiler chickens. Therefore th...

Background and Aims: Influenza vaccination is one of the best way to prevent and control influenza worldwide. It is manufactured by WHO-licensed companies based on the WHO expertise committee annually. The aim of this study was partial quality control of the commercial human influenza vaccine 2008-9 and its matching with the circulating strains. Materials and Methods: The trivalent imported vac...