In the present study, the effects of morphine sensitization on morphine-induced impairment of memory formation and the state-dependent retrieval of a passive avoidance task learned under morphine influence have been investigated in mice. Pre-training administration of morphine (0.5, 2.5 and 5 mg/kg) dose dependently suppressed the learning of one-trial passive avoidance task. Pre-test administr...

In the present study, the effects of morphine sensitization on morphine-induced impairment of memory formation and the state-dependent retrieval of a passive avoidance task learned under morphine influence have been investigated in mice. Pre-training administration of morphine (0.5, 2.5 and 5 mg/kg) dose dependently suppressed the learning of one-trial passive avoidance task. Pre-test administr...

Introduction: Exposure to 3, 4- methylenedioxymethamphetamine (MDMA) could lead to serotonergic system toxicity in the brain. This system is responsible for learning and memory functions. Studies show that MDMA causes memory impairment dose-dependently and acutely. The present study was designed to evaluate the chronic and acute effects of MDMD on spatial memory and acquisition of passive avoid...

objective : in this study, the effects of estradiol valerate and raloxifenea selective estrogen receptor modulator; (serm) on morphine induced sensitization were examined in mice memory, according to the step-down passive avoidance task. method: the mice received morphine or estradiol and raloxifene for three days alone or in combination with morphine. after a drug free period of 5 days, the su...

background: different stressors induce learning and memory impairment and physical activity influence learning and memory enhancement. in this research, we investigated the effect of synchronized running activity with stress on acquisition and retention time of passive avoidance test. methods: male wistar rats were randomly divided into five groups as follows: control (co), sham (sh), exercise ...

diabetes mellitus is accompanied with disturbances in learning, memory, and cognitive skills in the humans and experimental animals. due to the anti-diabetic and antioxidant activity of pelargonidin (pg), this research study was conducted to evaluate the efficacy of chronic oral pg on alleviating learning and memory disturbance in streptozotocin-diabetic rats. male wistar rats were divided into...

Background and Objective: Temporal lobe epilepsy (TLE) usually leads to memory deficit. In this study, we tried to assess the effect of Withania somnifera extract on the impaired learning and memory in the intrahippocampal kainate model of TLE in the rat. Materials & Methods: Male rats (n=32) were divided into sham, extract+sham, kainite, and kainite+extract. For induction of epilepsy, unilate...

Background and Objective: Based on the effect of chronic metabolic diseases including diabetes mellitus on the learning and memory, this study was designed to assess the usefulness of administration of salvialonic acid B on lessening of learning and memory deficits in streptozotocin (STZ)-diabetic rats. Materials and Methods: Male Wistar rats were allocated into control, salvialonic acid B-trea...

diabetes mellitus is accompanied with disturbances in learning, memory, and cognitive skills in the human society and experimental animals. therefore, this research study was conducted to evaluate time-dependent changes in passive avoidance and y-maze performance in male diabetic rats. for this purpose, male wistar rats were randomly divided into control and diabetic groups. for induction of di...