introduction: studies have shown the regulatory role of leptin in bone formation, its expression in adipose tissue as well as increased levels in circulation following the adminstration of inflammatory stimuli such as lipopolysaccharides (lps). however, there is little data evaluating the role of leptin in inflammatory periapical lesions. the aim of this study was to evaluate the presence and c...

This study was undertaken to investigate the distribution of mast cells (MCs) and the expression of transforming growth factor-β (TGF-β) on tryptase positive MCs in different types of human periapical diseases. Periapical tissues of 78 participates were used in this study, including healthy control (n=28), periapical cyst (n=25), and periapical granuloma (n=25). The tissue samples were fixed in...

persistent microorganisms in the root canal are known to cause endodontic treatments failure. overextended gutta-percha can also act as a periradicular tissue irritant, leading to large periapical lesions. retrieval of overextended gutta-percha with a nonsurgical approach can prove to be a challenge. this case describes the nonsurgical management of a large periapical lesion associated with ove...

conclusions the authors recommended to have paraclinical tests, especially vitality tests, in addition to clinical and radiographic examinations to avoid endodontic mistreatment. in suspicious cases, biopsy of lesions, referral to pathologist, and long-term fallow-up is required. context the essential role of a general dental practitioner is recognizing the nature of the oral cavity lesions. pe...

Periapical diseases are induced as a result of the direct or indirect involvement of oral bacteria. The etiologic factor being the degenerating pulp tissue. A periapical lesion is formed within an area of apical periodontitis which cannot form by itself and is inflammatory in origin. If the microbial etiology of periapical lesions and in the root canal is removed by nonsurgical root canal thera...

Most periapical lesions are associated with microorganisms from infected root canal systems. Maxillary sinus can pose a diagnostic dilemma radiographically because of its anatomical variation which can mimic a periapical pathosis. The aim of this study was to describe two cases of aberrant anatomical variation of the maxillary sinus that presented radiographic similarities to a periapical cyst ...

Objectives: To assess and compare five diagnostic imaging methods used in the identification of periapical diseases, of different diameters, mechanically simulated. Methods: The sample of the present study consisted of 12 dried human mandibles. Digital panoramic radiography, conventional and digital periapical radiography (charged couple device and photo-stimulable phosphor plate), and high-res...

background and aims. chronic periapical disease with pulpal origin is an inflammatory condition caused by bacterial infection. chronic infection could affect general health by increasing the production of cytokines such as interleukin-6 (il-6) that probably play a role in pathogenesis of pulpal and periapical diseases. the aim of the present study was a comparative evaluation of the level of se...

Objective The present study aimed to investigate the role of periapical diseases in inducing medication-related osteonecrosis of the jaws (MRONJ) using an ovariectomized (OVX) mice model. Materials and Methods Twenty C57BL/6N female mice were randomly assigned to two groups. All mice were subjected to bilateral ovariectomy and then treated with oncologic dose of zoledronic acid (ZA) or vehicl...