phenylketonuria (pku) is an autosomal recessive disorder, which is characterized by severe mental retardation, microcephaly and seizures. the symptoms of this disease can be prevented if detected soon after birth. therefore, blood phenylalanine (phe) measurement is essential for the early diagnosis, treatment and dietary monitoring of pku patients. the goal of this research was to introduce a r...

the purpose of the current research is investigating the phenylalanine removal by using magnetic nanoparticles (fe3o4) from water samples. the effect of ph, contact time and phenylalanine concentration on phenylalanine adsorption efficiency by magnetite nanoparticles are studied in a batch system. transmission electron microscopy (tem), x-ray diffraction patterns (xrd) and fourier transform inf...

The purpose of the current research is investigating the phenylalanine removal by using magnetic nanoparticles (Fe3O4) from water samples. The effect of pH, contact time and phenylalanine concentration on phenylalanine adsorption efficiency by magnetite nanoparticles are studied in a batch system. Transmission electron microscopy (TEM), X-ray Diffraction Patterns (XRD) and...

background there is evidence in support of low bone density in young patients with disorders of phenylalanine metabolism; however, little is known about muscle and fat mass in these patients, especially in those with mild hyperphenylalaninemia (mhpa). objectives we aimed to evaluate body composition of children and adolescents with early-diagnosed disorders of phenylalanine metabolism. patients...

Pancytopenia in childhood can be caused by a variety of underlying diseases including hematological and non-hematological entities. Phenylketonuria (PKU) is an inborn error of phenylalanine metabolism. No association between PKU and pancytopenia has ever been reported. We report the first case of PKU revealed by a pancytopenia at presentation. The patient was an infant girl born to healthy non-...

cloning and expression of the l-phenylalanine dehydrogenase gene, from b. sphaericus in e. coli were done. the gene was cloned in the vector pet16b and transformed into e. coli bl21 (de3). the functional form of the l-phenylalanine dehydrogenase enzyme was purified by affinity purification techniques, taking advantage of the ability of this enzyme to bind to the nucleotide site affinity dye, re...

Phenylalanine ammonia-lyase (PAL) links the plant primary and secondary metabolisms, its product, trans-cinnamic acid, is derived into thousands of diverse phenylpropanoids. Bambusa oldhamii BoPAL4 has broad substrate specificity using L-phenylalanine, L-tyrosine, L-3,4-dihydroxy phenylalanine (L-DOPA) as substrates to yield p-coumaric caffeic respectively. The optimum reaction pH for three was...