The FMR1 gene partially appears to control ovarian reserve, with a specific ovarian sub-genotype statistically associated with a polycystic ovary (PCO)- like phenotype. Some forms of PCO have been associated with autoimmunity. We, therefore, investigated in multiple regression analyses associations of ovary-specific FMR1 genotypes with autoimmunity and pregnancy chances (with in vitro fertiliza...

BACKGROUND Single-nucleotide polymorphisms (SNPs) in the follicle stimulating hormone receptor (FSHR) gene are associated with PCOS. However, their relationship to the polycystic ovary (PCO) morphology remains unknown. This study aimed to investigate whether PCOS related SNPs in the FSHR gene are associated with PCO in women with PCOS. METHODS Patients were grouped into PCO (n = 384) and non-...

Background: Hirsutism, a common clinical condition, not onlycauses cosmetic concern but may also be a sign of underlyingdisease. Polycystic ovary syndrome (PCOS) is an importantand common cause of hirsutism. In fact, many women withPCOS present as hirsutism. This study assessed young Kashmiriwomen presenting as hirsutism, for ultrasonographic evidence ofpolycystic ovaries (PCO), in addition to ...

The polycystic ovary syndrome (originally called the Stein–Leventhal syndrome), was popularized by the two Americans whose names have been attached to the condition for 70 years (Stein and Leventhal 1935), and was considered as a problem of anovulation and infertility. They described their treatment of anovulation using wedge resection with remarkable success. However as medical treatment becam...

Polycystic-appearing ovaries (PAO) on ultrasound have been described in a variety of endocrinopathies and also occur in ovulatory women. By some investigators this is merely referred to as 'PCO' (polycystic ovaries). Although there is controversy in this regard, we do not consider women with PAO/PCO who have no known endocrine disturbance to have polycystic ovary syndrome (PCOS) and therefore p...

Histological studies have demonstrated that polycystic ovaries (PCO) contain increased numbers of preantral follicles with a specific increase in primary follicles. Polycystic ovary syndrome is associated with hyperandrogenism and pre- and postnatal androgenization of primates increases the pool of growing follicles producing changes resembling PCO. In vitro studies could test the hypothesis th...

OBJECTIVE Patients with polycystic ovary syndrome (PCOS) diagnosed with the 1990 criteria (i.e. presence of oligo- and/or anovulation (ANOV) and hyperandrogenemia and/or hyperandrogenism (HA) with or without polycystic ovaries (PCO)) appear to have a more adverse metabolic profile than patients diagnosed with the additional criteria introduced in 2003 (i.e. presence of HA and PCO without ANOV a...