cytokines influence cell cycle events, which in some but not all instances can be associated with melanoma progression. analysis of the g0/g 1 and s phase fractions of the cell cycle was used to assay the proliferative or inhibitory activity of cytokines against ten human melanoma cell lines, including pairs of cell lines derived from primary and metastatic tissue of individual patients. cytoki...

Although gastrointestinal involvement by metastatic malignant melanoma is common but primary gastrointestinal (GI) melanoma has been reported in rare cases. In this study we report two cases of primary gastrointestinal malignant melanoma that one of them is a known case of neurofibromatosis type 1(NF1). Both cases showed no evidence of any lesions in skin and eye. Malignant melanoma of GI tract...

although gastrointestinal involvement by metastatic malignant melanoma is common but primary gastrointestinal (gi) melanoma has been reported in rare cases. in this study we report two cases of primary gastrointestinal malignant melanoma that one of them is a known case of neurofibromatosis type 1(nf1). both cases showed no evidence of any lesions in skin and eye. malignant melanoma of gi tract...

  Background: Melanoma causes the greatest morbidity and mortality of all skin cancers. Mucosal melanoma is a rare but highly aggressive neoplasm. According to previous studies the prevalence of KIT mutations in acrallentiginous and mucosal melanomas is relatively low (less than 15–20%), but it can have profound therapeutic implications for localized high risk or metastatic diseases. Our goal w...

background: melanoma causes the greatest morbidity and mortality of all skin cancers. mucosal melanoma is a rare but highly aggressive neoplasm. according to previous studies the prevalence of kit mutations in acrallentiginous and mucosal melanomas is relatively low (less than 15–20%), but it can have profound therapeutic implications for localized high risk or metastatic diseases. our goal was...

Cytokines influence cell cycle events, which in some but not all instances can be associated with melanoma progression. Analysis of the G0/G 1 and S phase fractions of the cell cycle was used to assay the proliferative or inhibitory activity of cytokines against ten human melanoma cell lines, including pairs of cell lines derived from primary and metastatic tissue of individual patients. Cy...

Objective(s): Malignant melanoma is the most lethal type of skin cancers with unfavorable prognosis. Alpha-MSH peptide analogues have a high affinity for melanocortine-1 (MC1) receptors on melanocytes overexpressing in malignant melanoma cells. Pre-clinical studies have shown promising results for radiolabeled MSH imaging in this malignancy. The purpose of this study is to assess the diagnostic...

Background: Malignant melanoma is the leading cause of death among skin cancers in western countries. However, the incidence, histologic subtypes, and tumor behaviors are quite different in Asians and western populations. Objective: This study was designed to survey the clinicopathological aspects of malignant melanoma among Khouzestan people. Patients and Methods: In a retrospective stud...

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Melanoma incidence and survival are age-dependent, with older patients having both higher rates worse outcomes. Here, we seek to examine age-dependent differences in mutational profiles of cutaneous melanoma, which may impact melanoma prognosis treatment-related Mutational 2263 were extracted from the American Association for Cancer Research Project Genomics Evidence Neoplasia Information Excha...