Chemical immunotherapeutic strategies including Antibody Recruiting Molecules (ARMs - bivalent small molecules containing an antibody-binding domain (ABD) and a target-binding (TBD)) direct immune-mediated clearance of diseased cells. Anti-cancer ARM function relies on high tumor antigen valency, limiting against lower expressing tumors. To address this limitation, we report tunable multivalent...

Miyamoto and colleagues present data that prostate-specific antigen/prostate-specific membrane antigen (PSA/PSMA)-based measurements of androgen receptor (AR) signaling in circulating tumor cells (CTC) enable real-time quantitative monitoring of intratumoral AR signaling. This finding indicates that measuring AR signaling within CTCs may help to guide therapy in metastatic prostate cancer and h...

The Prostate Specific Membrane Antigen (PSMA) is considered to be the most well established target antigen in prostate cancer, since it is highly and specifically expressed at all tumor stages on the surface of prostate tumor cells. This chapter outlines the structure, function, and expression of PSMA, its relevance as prognostic and diagnostic biomarker, and different therapeutic approaches ta...