Glycation is a protein modification, which results in a change in a protein structure. Glycation is believed to be the etiology of various age-related diseases such as diabetes mellitus and Alz-heimer’s disease (AD). Activation of microglia and resident macrophages in the brain by glycated proteins with subsequent oxidative stress and cytokine release may be an important factor in the progressi...

C-reactive protein (CRP) is a phylogenetically highly conserved plasma protein, with homologs in vertebrates and many invertebrates, that participates in the systemic response to inflammation. Its plasma concentration increases during inflammatory states, a characteristic that has long been employed for clinical purposes. CRP is a pattern recognition molecule, binding to specific molecular conf...

Researchers in the post-genome era are confronted with the daunting task of assigning structure and function to tens of thousands of encoded proteins. To realize this goal, new technologies are emerging for the analysis of protein function on a global scale, such as activity-based protein profiling (ABPP), which aims to develop active site-directed chemical probes for enzyme analysis in whole p...

seed storage proteins are synthesized as sources of carbon, nitrogen and sulfur for the next generation of plants. reactive oxygen species serve as second messengers for signal transduction; however, molecular targets of oxidant signaling have not been defined. here, many researchers showes that ligand–receptor mediated signaling promotes reactive oxygen species– dependent protein carbonylation...

background: polycystic ovary syndrome (pcos) is a common disorder of infertility which affects more than 100 million women. it is characterized by chronic anovulation, hyper androgenism and obesity. pcos is also associated with oxidative stress changes. objective: here, we aimed to investigate the level of antioxidants and oxidative stress in iranian women with pcos as a predictive factor for c...

glycation is a protein modification, which results in a change in a protein structure. glycation is believed to be the etiology of various age-related diseases such as diabetes mellitus and alz-heimer’s disease (ad). activation of microglia and resident macrophages in the brain by glycated proteins with subsequent oxidative stress and cytokine release may be an important factor in the progressi...