in this study, we investigated the cardioprotective effects of resveratrol. rats were intraperitoneally administered with resveratrol (25 mg/kg bw) or vehicle (ethanol 10%) for 7 days and their heart subjected to ischemia/reperfusion injury. isolated hearts were langendorff perfused, left ventricular functions as heart rate and developed pressure, as well as, heart antioxidant status were deter...

objective: resveratrol, a phytoalexin, has a wide range of desirable biological actions. despite a growing body of evidence indicating that resveratrol induces changes in neuronal function, little effort, if any, has been made to investigate the cellular effect of resveratrol treatment on intrinsic neuronal properties. materials and methods: this experimental study was performed to examine the ...

background: recent studies demonstrated that resveratrol has many therapeutic effects on liver disorders. resveratrol significantly increased survival after liver transplantation, decreased fat deposition, necrosis, and apoptosis which induced by ischemia in wistar rats. it provided liver protection against chemical, cholestatic, and alcohol injury. resveratrol can improve glucose metabolism an...

Introduction: Aging involves a decrease in  physiological function, physical activity and nutrition that modulate body functions. The aim of this study was to evaluate the effect of a six week-swimming interval training with resveratrol consumption on apoptotic markers in the liver tissue of aged rat. Methods: In this experimental study, thirty-two 20-month aged rats weighing 350-370 g were di...

conclusions in lighting conditions, most of t-res was isomerized to the other isomer cis-resveratrol. t-res is unstable in alkali ph and when exposed to light. t-res was quite stable at other conditions, and several freeze-thaw cycles did not have any effect on its stability. results our findings revealed that t-res was quite stable in different temperatures ranging from -70 °c to 25 °c, and ac...

background: glucose uptake by muscles and fat cells is carried out by the glut4 system. isoforms of the snap23, syntaxin-4 and vamp-2 play an important role in regulating glut-4 trafficking and fusion in adipocytes. the changes of snare proteins levels and thus impaired glut-4 displacement can be one of the etiological causes of type 2 diabetes. due to changes in the expression of these protein...

Introduction: Resveratrol (3,5,4-trihydroxystilbene) a non-flavonoid polyphenol found in some plants like grapes, peanuts and pomegranates, possesses a wide range of biological effects. Evidence indicates that resveratrol has beneficial effects on nervous system to induce neuroprotection. However, the cellular mechanisms of the effects are not fully determined. In the present study, the cellula...

background: resveratrol has beneficial effects on cardiovascular system. this study aimed at examining antidiabetic and antihypertensive effects of resveratrol in rats with simultaneous type 2 diabetes and renal hypertension. methods: eight groups (8-10 each) of male spargue-dawley rats, including a control, a diabetic (induced by streptozotocin and nicotinamide), a renal hypertensive (induced ...