نتایج جستجو برای: resveratrol
تعداد نتایج: 7841 فیلتر نتایج به سال:
objective(s): the study aimed to investigate the effects of resveratrol on colorectal cancer hct116 cells, including cell viability, apoptosis, and migration, and the partial mechanisms focused on hedgehog/gli-1 signaling pathways. materials and methods: we chose the appropriate time and concentration of recombinant human sonic hedgehog (shh) stimulation by cell viability. the proportion of cel...
Introduction: Urinary tract infections are common causes of outpatient referrals to medical centers. Acute pyelonephritis is often treated by injectable antibiotics. Side effects, especially resistance to antibiotics, considered the use of non-antibiotic compounds. Resveratrol, which is found in grapes, is a powerful antioxidant, anti-inflammatory and anti-bacterial as well. In this study, the ...
Introduction: Diazinon is used as an organophosphate pesticide in agriculture. Studies showed that a lot of organophosphates can produce free radicals and disrupt antioxidant system. Resveratrol as an antioxidant can reduce oxidative stress in kidney tissue. The study aimed to investigate the protective role of resveratrol on oxidative stress induced by sub-acute diazinon exposure in kidney tis...
Introduction: Non-alcoholic fatty liver disease (NAFLD) is a condition in which triglycerides accumulate in liver cells without a history of alcohol consumption. Evidence has shown that auxiliary treatments, including the use of antioxidant compounds, can be effective in improving nonalcoholic fatty liver. Resveratrol is an antioxidant compound that has been shown to be beneficial in some disea...
Background: The present study was conducted to investigate the effect of aerobic training with resveratrol supplementation on regulatory and executive factors of cardiomyocytes apoptosis in streptozocin diabetic male rats. Materials and methods: In an experimental study, 50 male rats were randomly divided into 5 groups of 10 healthy controls, diabetics, resveratrol supplements, aerobic training...
Resveratrol is a naturally occurring polyphenolic compound with various pharmacological activities. It is unknown whether the expression of metabolizing enzymes correlates with resveratrol levels in organs and tissues. Therefore, we investigated the metabolism and tissue distribution of resveratrol in mice and assessed its association with the expression of UDP-glucuronosyltransferase (Ugt) and...
We investigated the role of resveratrol, a polyphenol rich in red wine, in cell cycle progression and apoptosis of vascular smooth muscle cells (VSMCs). Resveratrol inhibited the growth of human aortic VSMCs at concentrations as low as 1 microM. This was due to the profound dose-dependent inhibition of DNA synthesis by resveratrol. DNA synthesis was more effectively inhibited when cells were pr...
PURPOSE This study aimed to investigate the neuroprotective effect of resveratrol in an optic nerve transection (ONT) model and to identify the neuroprotective mechanism of resveratrol in retinal ganglion cells (RGCs). METHODS ONT and retrograde labeling were performed in Sprague-Dawley rats. Various concentrations of resveratrol were injected intravitreally immediately after ONT. The number ...
PURPOSES Resveratrol is a phenolic compound found in grapes and other food products. In order to assess the availability of resveratrol as an angio-inhibiting drug, we examined whether resveratrol plays an important role in bovine aortic endothelial cells (BAECs) for cell apoptosis and cell migration. METHODS AND MATERIALS Endothelial cell apoptosis was observed as detected by the Hoechst sta...
Resveratrol (RSV) is a natural polyphenol that has a beneficial effect on health, and resveratrol-induced autophagy has been suggested to be a key process in mediating many beneficial effects of resveratrol, such as reduction of inflammation and induction of cancer cell death. Although various resveratrol targets have been suggested, the molecule that mediates resveratrol-induced autophagy rema...
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