Chronic pelvic pain is a debilitating, life-altering syndrome that negatively affects a woman's quality of life and personal relationships. Many women continue to suffer with pelvic pain despite having undergone multiple medical and surgical treatments. Unfortunately, some women are incorrectly labeled as having psychological illness when organic disease may be present. I report a case of a wom...

In this paper, we prove a general form of a fixed point theorem with contractive-like mapping defined by altering function. We also present its application on study of existence and uniqueness of solution of fuzzy initial value problems in fuzzy partial metric spaces. In order to do this, we recall some fixed point theorems in partial metric spaces either crisp or fuzzy and use these theorems t...

Ephs regulate growth cone repulsion, a process controlled by the actin cytoskeleton. The guanine nucleotide exchange factor (GEF) ephexin1 interacts with EphA4 and has been suggested to mediate the effect of EphA on the activity of Rho GTPases, key regulators of the cytoskeleton and axon guidance. Using cultured ephexin1-/- mouse neurons and RNA interference in the chick, we report that ephexin...

Let $G$ a semisimple Lie group of non-compact type and let $\mathcal{X}_G$ be the Riemannian symmetric space associated to it. Suppose has dimension $n$ it no factor isometric either $\mathbb{H}^2$ or $\text{SL}(3,\mathbb{R})/\text{SO}(3)$. Given closed $n$-dimensional manifold $N$, $\Gamma=\pi_1(N)$ its fundamental $Y$ universal cover. Consider representation $\rho:\Gamma \rightarrow G$ with m...

Whenever a finitely generated group $G$ acts properly discontinuously by isometries on metric space $X$, there is an induced uniform embedding (a Lipschitz and uniformly proper map) $\rho: G \rightarrow X$ given mapping to orbit. We study when difference between acting contractible $n$-manifold into $n$-manifold. For example, Kapovich Kleiner showed that are torsion-free hyperbolic groups embed...

Non-viral gene delivery into human embryonic stem cells (hESCs)is an important tool for controlling cell fate. However, the delivery efficiency remains low due in part to the tight colony structure of the cells which prevents effective exposure towards delivery vectors. We herein report a novel approach to enhance non-viral gene delivery to hESCs by transiently altering the cell and colony stru...

Integrin adhesion receptors connect the extracellular matrix (ECM) to the cytoskeleton and serve as bidirectional mechanotransducers. During development, angiogenesis, wound healing and cancer progression, the relative abundance of fibronectin receptors, including integrins α5β1 and αvβ3, changes, thus altering the integrin composition of cell-matrix adhesions. Here, we show that enhanced αvβ3 ...