abstractbackground: this study aimed to present a rare case of neu-laxova syndrome (nls) and review the newly revealed genetic features of the disease in hopes to find a way for early interventions.case report: female newborn with nls was born at 30 weeks of gestation to consanguineous parents. the last prenatal ultrasound imaging revealed severe intrauterine growth restriction and microcephaly...

the present study describes the fragmentation under electron ionization (ei) of gas phase serine and threonine amino acids. ab initio methods were performed to calculate the fragmentation paths and interpret the mass spectra. the six lowest energy conformers of l-serine, l-threonine and l-allo-threonine were obtained with b3lyp, g3mp2 and mp2 methods. the adiabatic and vertical ionization energ...

oxidative stress has been implicated as a prominent determinant in the development of several diseases such as atherosclerosis. anti atherosclerotic effects of l-serine have been shown previously but its responsible mechanisms remained unidentified .this study aimed to investigate the antioxidant and cytoprotecrtive effects of l-serine and its possible mechanisms. for this purpose ,cell viabili...

background l-tryptophan is an important ingredient in medicines, especially in neuromedicines such as antidepressants. many commercial processes employ various microorganisms with high tryptophan synthase activity to produce l-tryptophan from indole and l-serine, but these processes are very costly due to the costs of precursors, especially l-serine. objectives for this reason, we studied the a...

Background and Objectives: Our aim was to evaluate the association between dietary serine intakes and hypertension incident. Materials and Methods: We used the data of 4287 subjects aged 20-70 years, who participated in the fourth phase of Tehran Lipid and Glucose Study (2008-2011)  and were followed up to the fifth  phase (2011-2014). At baseline, the participants were free of hyp...

     The aim of this study was to use site directed mutagenesis technique to construct a vector in which serine363 and serine375 residues of the COOH-terminal portion of the μ-opioid receptor (MOR) were substituted by alanine. These constructs are essential in studying G-protein coupled receptor kinase-mediated MOR desensiti-zation. The nested PCR carried out for conversio...

Adverse outcome of pregnancy is a potentially dangerous complication of conception and affects 15-20% of pregnancies. According to recent studies increased level of blood antiphospholipids antibodies, if accompanied by predisposing factors, can be an adverse event in human pregnancy. The aim of the present study was to compare the maternal serum levels of anticardiolipin and antiphosphatidyl se...

Background and Objective: Serine and glycine are connecting lines for biosynthesis and are essential resources for synthesis of proteins, nucleic acids and lipids that are necessary for cancer cell growth. The purpose of this study was to set a comparison of serine and glycine in patients with esophageal cancer and in healthy people. Materials and Methods: 37 plasma samples were collected from...