Gastrointestinal (GI) complications during diabetes mellitus (DM) are common. Attempts to ascribe changes in the glycemic state to the altered GI (gastrointestinal) motility in experimental models yielded varied results. In the present study the possible cause-effect relationship between the changes in the glycemic, insulinemic states and small intestinal transit (SIT) in normal mice was examin...

background: regular physical exercise is a well-established therapeutic option to prevent the diabetes mellitus. the purpose of this study was to examine the effects of intense interval training (sit (and combined aerobic-strength training on serum adiponectin level and insulin resistance  in women with type 2 diabetes. materials and methods: female patients with type 2 diabetic (n=52, age: 45-...

BACKGROUND Allergen-specific immunotherapy (SIT) has been used since 1911, yet its mechanism of action remains to be elucidated. There is evidence indicating that CD4(+)FOXP3(+) regulatory T cells (Treg cells) are induced during SIT in allergic patients. However, the contribution of these cells to SIT has not been evaluated in vivo. OBJECTIVE To evaluate the in vivo contribution of (i) CD4(+)...

Pioglitazone (PIO) and glucagon-like peptide-1 (GLP-1) analogs limit infarct size (IS) in experimental models. The effects of the dipeptidyl-peptidase-IV inhibitors, which increase the endogenous levels of GLP-1, on myocardial protection, are unknown. We studied whether sitagliptin (SIT) and PIO have additive effects on IS limitation in the mouse. Mice received 3-day or 14-day oral SIT (300 mg....

Results 252 respiratory physicians were enrolled and 224 effective questionnaire were included in analysis. Among the 224 physicians, 92.9% had heard of SIT before and 75.9% regard SIT as an effective treatment in allergic diseases. However, only 55.8% thought SIT was proved to be effective in asthma.43.8% of the physicians agreed with that SIT had a long-term efficacy, 23.7% knew that there we...

PURPOSE Specific immunotherapy (SIT) is a suitable but uncommon treatment option for allergic rhinitis (AR) in China. The current understanding and attitude of Chinese ENT (ear, nose, and throat) specialists in regards to SIT is unclear. This study investigates current trends in the awareness and application status of SIT among Chinese ENT specialists. METHODS We performed a nationwide, cross...